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mxt-1 Eukaryotic translation initiation factor 4E-binding protein Mextli homolog [ Caenorhabditis elegans ]

Gene ID: 173151, updated on 4-Jan-2025

Summary

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Official Symbol
mxt-1
Official Full Name
Eukaryotic translation initiation factor 4E-binding protein Mextli homolog
Primary source
WormBase:WBGene00012478
Locus tag
CELE_Y18D10A.8
See related
AllianceGenome:WB:WBGene00012478
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable eukaryotic initiation factor 4E binding activity and translation initiation factor activity. Predicted to be involved in positive regulation of translation and regulation of formation of translation initiation ternary complex. Predicted to be part of RNA cap binding activity complex. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See mxt-1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
9
Sequence:
Chromosome: I; NC_003279.8 (12844269..12853130)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Sodium/hydrogen exchanger Neighboring gene ncRNA Neighboring gene SSD domain-containing protein Neighboring gene putative cytosolic iron-sulfur protein assembly protein CIAO1 homolog Neighboring gene C-type lectin domain-containing protein Neighboring gene Dynein regulatory complex subunit 4

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mextli proteins use both canonical bipartite and novel tripartite binding modes to form eIF4E complexes that display differential sensitivity to 4E-BP regulation. Peter D, et al. Genes Dev, 2015 Sep 1. PMID 26294658, Free PMC Article
  2. A protein domain-based interactome network for C. elegans early embryogenesis. Boxem M, et al. Cell, 2008 Aug 8. PMID 18692475, Free PMC Article
  3. Empirically controlled mapping of the Caenorhabditis elegans protein-protein interactome network. Simonis N, et al. Nat Methods, 2009 Jan. PMID 19123269, Free PMC Article
  4. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article
  5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables eukaryotic initiation factor 4E binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables eukaryotic initiation factor 4E binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables translation initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in positive regulation of translation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of translation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of formation of translation initiation ternary complex IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of RNA cap binding complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Eukaryotic translation initiation factor 4E-binding protein Mextli homolog
NP_493246.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    12844269..12853130
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_060845.6 → NP_493246.1  Eukaryotic translation initiation factor 4E-binding protein Mextli homolog [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_493246.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9XW13
    Conserved Domains (1) summary
    cd00105
    Location:246 → 307
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9XW13.1

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