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mcrs-1 FHA domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 173133, updated on 9-Dec-2024

Summary

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Official Symbol
mcrs-1
Official Full Name
FHA domain-containing protein
Primary source
WormBase:WBGene00010420
Locus tag
CELE_H28O16.2
See related
AllianceGenome:WB:WBGene00010420
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable G-quadruplex RNA binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be part of NSL complex. Orthologous to human MCRS1 (microspherule protein 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See mcrs-1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
8
Sequence:
Chromosome: I; NC_003279.8 (12647380..12652087, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene pseudo Neighboring gene ncRNA Neighboring gene ATP synthase subunit alpha, mitochondrial Neighboring gene ATP synthase subunit alpha, mitochondrial

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A combined binary interaction and phenotypic map of C. elegans cell polarity proteins. Koorman T, et al. Nat Cell Biol, 2016 Mar. PMID 26780296, Free PMC Article
  2. Defect-buffering cellular plasticity increases robustness of metazoan embryogenesis. Xiao L, et al. Cell Syst, 2022 Aug 17. PMID 35882226
  3. A modified TurboID approach identifies tissue-specific centriolar components in C. elegans. Holzer E, et al. PLoS Genet, 2022 Apr. PMID 35442950, Free PMC Article
  4. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
  5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables G-quadruplex RNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of Ino80 complex IEA
Inferred from Electronic Annotation
more info
  
part_of MLL1 complex IEA
Inferred from Electronic Annotation
more info
  
part_of NSL complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
FHA domain-containing protein
NP_493201.3
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    12647380..12652087 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_060800.9 → NP_493201.3  FHA domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_493201.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5ED60
    Conserved Domains (2) summary
    cd00060
    Location:326 → 410
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    pfam13325
    Location:107 → 249
    MCRS_N; N-terminal region of micro-spherule protein
Nucleotide Protein
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