ced-1 Cell death abnormality protein 1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: ced-1
Official Full Name: Cell death abnormality protein 1
Primary source: WormBase:WBGene00000415
Locus tag: CELE_Y47H9C.4
See related: AllianceGenome:WB:WBGene00000415
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables scavenger receptor activity. Involved in several processes, including cytoskeleton organization; left/right axis specification; and phagocytosis. Located in several cellular components, including phagocytic cup; phagocytic vesicle membrane; and pseudopodium membrane. Is expressed in several structures, including engulfing cell; hypodermis; intestinal cell; muscle cell; and neurons. Human ortholog(s) of this gene implicated in congenital myopathy 10B and early-onset myopathy-areflexia-respiratory distress-dysphagia syndrome. Orthologous to several human genes including MEGF10 (multiple EGF like domains 10) and MEGF11 (multiple EGF like domains 11). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See ced-1 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 11

Sequence:: Chromosome: I; NC_003279.8 (11851554..11868105, complement)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phagocytosing muscle cells promote neuronal regeneration and remove neuronal debris through distinct biochemical functions of CED-1.
Title: Engulfing cells promote neuronal regeneration and remove neuronal debris through distinct biochemical functions of CED-1.
The formation of such halos depends on the integrins PAT-2/PAT-3, UNC-112 and the GEF protein UIG-1, but not on the canonical ced-1/6/7 or ced-2/5/12 signaling modules.
Title: Small GTPase CDC-42 promotes apoptotic cell corpse clearance in response to PAT-2 and CED-1 in C. elegans.
CED-7 and TTR-52 may promote the efflux of PS from apoptotic cells through the generation of extracellular phosphatidylserine (PS) vesicles, which lead to exoplasmic leaflet (exPS) expression on phagocytes via TTR-52 and CED-1 to facilitate cell corpse clearance.
Title: CED-1, CED-7, and TTR-52 regulate surface phosphatidylserine expression on apoptotic and phagocytic cells.
TTR-52 is therefore the first bridging molecule identified in C. elegans that mediates recognition of apoptotic cells by crosslinking the PtdSer 'eat me' signal with the phagocyte receptor CED-1.
Title: Caenorhabditis elegans transthyretin-like protein TTR-52 mediates recognition of apoptotic cells by the CED-1 phagocyte receptor.
study found that the intracellular protein sorting complex, retromer, was required for cell corpse clearance by mediating the recycling of CED-1; retromer probably acted through direct interaction with CED-1 in the cell corpse recognition pathway
Title: Retromer is required for apoptotic cell clearance by phagocytic receptor recycling.
CED-1/SCARF1 and C03F11.3/CD36 are beta-glucan binding receptors and define an evolutionarily conserved pathway for the innate sensing of fungal pathogens.
Title: Evolutionarily conserved recognition and innate immunity to fungal pathogens by the scavenger receptors SCARF1 and CD36.
Unfolded protein response genes regulated by ced-1 are required for Caenorhabditis elegans innate immunity.
Title: Unfolded protein response genes regulated by CED-1 are required for Caenorhabditis elegans innate immunity.
Phagocytic receptors, which were thought to act specifically in initiating engulfment, also control phagosome maturation through the sequential activation of multiple effectors such as dynamin, PI(3)P, and Rab GTPases.
Title: Phagocytic receptor CED-1 initiates a signaling pathway for degrading engulfed apoptotic cells.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Y47H9C.4 (e-PCR)
- UniSTS:312996

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables scavenger receptor activity	IEA Inferred from Electronic Annotation more info
enables scavenger receptor activity	IPI Inferred from Physical Interaction more info	PubMed
enables scavenger receptor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in actin cytoskeleton organization	IDA Inferred from Direct Assay more info	PubMed
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in apoptotic process involved in development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in apoptotic process involved in development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to unfolded protein	IDA Inferred from Direct Assay more info	PubMed
involved_in defense response to bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in engulfment of apoptotic cell	IDA Inferred from Direct Assay more info	PubMed
involved_in engulfment of apoptotic cell	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment of mitotic spindle orientation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in establishment of protein localization	IDA Inferred from Direct Assay more info	PubMed
involved_in left/right axis specification	IGI Inferred from Genetic Interaction more info	PubMed
involved_in phagolysosome assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of apoptotic process involved in development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of apoptotic process involved in development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of distal tip cell migration	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of distal tip cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of engulfment of apoptotic cell	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of engulfment of apoptotic cell	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in programmed cell death	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in recognition of apoptotic cell	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in phagocytic cup	IDA Inferred from Direct Assay more info	PubMed
located_in phagocytic vesicle membrane	IDA Inferred from Direct Assay more info	PubMed
located_in phagocytic vesicle membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in pseudopodium membrane	IDA Inferred from Direct Assay more info	PubMed