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pgrn-1 Granulins domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 173054, updated on 14-Nov-2024

Summary

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Official Symbol
pgrn-1
Official Full Name
Granulins domain-containing protein
Primary source
WormBase:WBGene00011936
Locus tag
CELE_T22H2.6
See related
AllianceGenome:WB:WBGene00011936
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to be located in membrane. Predicted to be active in extracellular region. Is expressed in coelomocyte; intestine; neurons; and pseudocoelom. Used to study frontotemporal dementia. Human ortholog(s) of this gene implicated in dementia (multiple); neurodegenerative disease (multiple); neuronal ceroid lipofuscinosis 11; and primary progressive multiple sclerosis. Orthologous to human GRN (granulin precursor). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See pgrn-1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
4
Sequence:
Chromosome: I; NC_003279.8 (11701852..11703698)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene 4Fe-4S ferredoxin-type domain-containing protein Neighboring gene Serpentine Receptor, class I Neighboring gene G protein-coupled receptor Neighboring gene pseudo Neighboring gene ncRNA Neighboring gene Acyl_transf_3 domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The progranulin cleavage product granulin 3 exerts a dominant negative effect on animal fitness. Wang AL, et al. Hum Mol Genet, 2024 Jan 20. PMID 37903062, Free PMC Article
  2. Chemical and genetic rescue of in vivo progranulin-deficient lysosomal and autophagic defects. Doyle JJ, et al. Proc Natl Acad Sci U S A, 2021 Jun 22. PMID 34140407, Free PMC Article
  3. The Use of Caenorhabditis elegans to Study Progranulin in the Regulation of Programmed Cell Death and Stress Response. Hsu TY, et al. Methods Mol Biol, 2018. PMID 29956278
  4. Methods to Investigate the Molecular Basis of Progranulin Action on Neurons In Vivo Using Caenorhabditis elegans. Doyle JJ, et al. Methods Mol Biol, 2018. PMID 29956277
  5. The Progranulin Cleavage Products, Granulins, Exacerbate TDP-43 Toxicity and Increase TDP-43 Levels. Salazar DA, et al. J Neurosci, 2015 Jun 24. PMID 26109656, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The progranulin cleavage product granulin 3 exerts a dominant negative effect on animal fitness.
    Title: The progranulin cleavage product granulin 3 exerts a dominant negative effect on animal fitness.
  2. Chemical and genetic rescue of in vivo progranulin-deficient lysosomal and autophagic defects.
    Title: Chemical and genetic rescue of in vivo progranulin-deficient lysosomal and autophagic defects.
  3. Cells that might otherwise recover from damage or injury are destroyed in progranulin mutants, which in turn facilitates disease progression.
    Title: A neurodegenerative disease mutation that accelerates the clearance of apoptotic cells.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Granulins domain-containing protein
NP_492981.2
  • Confirmed by transcript evidence
NP_492982.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    11701852..11703698
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_060580.5 → NP_492981.2  Granulins domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A9J5DXX3

  2. NM_060581.7 → NP_492982.2  Granulins domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A9J5HVD3
Nucleotide Protein
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