rtel-1 Regulator of telomere elongation helicase 1 homolog [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: rtel-1
Official Full Name: Regulator of telomere elongation helicase 1 homolog
Primary source: WormBase:WBGene00009124
Locus tag: CELE_F25H2.13
See related: AllianceGenome:WB:WBGene00009124
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable ATP binding activity; DNA helicase activity; and DNA polymerase binding activity. Involved in regulation of double-strand break repair via homologous recombination. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in several diseases, including autosomal recessive dyskeratosis congenita 5; female breast cancer; gastric adenocarcinoma; high grade glioma (multiple); and lung disease (multiple). Orthologous to human RTEL1 (regulator of telomere elongation helicase 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See rtel-1 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 14

Sequence:: Chromosome: I; NC_003279.8 (10572029..10577135)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Analyses of jmjd-5 genetic interactions with genes required for resolving recombination intermediates (rtel-1) or promoting the resolution of RAD-51 double stranded DNA filaments (rfs-1 and helq-1) suggest that jmjd-5 prevents the formation of stalled postsynaptic recombination intermediates and favors RAD-51 removal.
Title: JMJD-5/KDM8 regulates H3K36me2 and is required for late steps of homologous recombination and genome integrity.
findings show that RTEL-1 is required to prevent excess meiotic crossovers, probably by promoting meiotic synthesis-dependent strand annealing
Title: RTEL-1 enforces meiotic crossover interference and homeostasis.
Study finds that rtel-1 mutant worms and RTEL1-depleted human cells share characteristic phenotypes with yeast srs2 mutants: lethality upon deletion of the sgs1/BLM homolog, hyperrecombination, and DNA damage sensitivity.
Title: RTEL1 maintains genomic stability by suppressing homologous recombination.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F25H2.12 (e-PCR)
- UniSTS:307536

F25H2.13 (e-PCR)
- UniSTS:309942

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables 4 iron, 4 sulfur cluster binding	IEA Inferred from Electronic Annotation more info
enables ATP binding	IBA Inferred from Biological aspect of Ancestor more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP binding	ISS Inferred from Sequence or Structural Similarity more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA helicase activity	IBA Inferred from Biological aspect of Ancestor more info
enables DNA helicase activity	IEA Inferred from Electronic Annotation more info
enables DNA helicase activity	ISS Inferred from Sequence or Structural Similarity more info
enables DNA polymerase binding	IBA Inferred from Biological aspect of Ancestor more info
enables helicase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA duplex unwinding	IBA Inferred from Biological aspect of Ancestor more info
involved_in DNA repair	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of DNA recombination	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of t-circle formation	IBA Inferred from Biological aspect of Ancestor more info
involved_in nucleobase-containing compound metabolic process	IEA Inferred from Electronic Annotation more info
involved_in regulation of double-strand break repair via homologous recombination	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of double-strand break repair via homologous recombination	IEA Inferred from Electronic Annotation more info
involved_in regulation of double-strand break repair via homologous recombination	IGI Inferred from Genetic Interaction more info	PubMed
involved_in telomeric loop disassembly	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: Regulator of telomere elongation helicase 1 homolog

NP_492769.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

10572029..10577135

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_060368.7 → NP_492769.1 Regulator of telomere elongation helicase 1 homolog [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_492769.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P90854, P90855, Q93575

Conserved Domains (3) summary

smart00488
Location:17 → 293

DEXDc2; DEAD-like helicases superfamily

TIGR00604
Location:16 → 761

rad3; DNA repair helicase (rad3)

pfam13307
Location:556 → 747

Helicase_C_2; Helicase C-terminal domain