U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

snx-27 Sorting nexin-27 [ Caenorhabditis elegans ]

Gene ID: 172937, updated on 4-Jan-2025

Summary

Go to the top of the page Help
Official Symbol
snx-27
Official Full Name
Sorting nexin-27
Primary source
WormBase:WBGene00009116
Locus tag
CELE_F25H2.2
See related
AllianceGenome:WB:WBGene00009116
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable phosphatidylinositol binding activity. Predicted to be involved in endocytic recycling and intracellular protein transport. Predicted to be active in early endosome. Orthologous to human SNX27 (sorting nexin 27). [provided by Alliance of Genome Resources, Jan 2025]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See snx-27 in Genome Data Viewer
Location:
chromosome: I
Exon count:
6
Sequence:
Chromosome: I; NC_003279.8 (10543024..10546429)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene MARVEL domain-containing protein Neighboring gene CUE domain-containing protein Neighboring gene ANK_REP_REGION domain-containing protein Neighboring gene MPN domain-containing protein

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. SNX27: A trans-species cognitive modulator with implications for anxiety and stress susceptibility. Armada G, et al. Neurobiol Stress, 2024 May. PMID 38500791, Free PMC Article
  2. SNX-3 mediates retromer-independent tubular endosomal recycling by opposing EEA-1-facilitated trafficking. Tian Y, et al. PLoS Genet, 2021 Jun. PMID 34081703, Free PMC Article
  3. Retromer is required for apoptotic cell clearance by phagocytic receptor recycling. Chen D, et al. Science, 2010 Mar 5. PMID 20133524
  4. A specificity map for the PDZ domain family. Tonikian R, et al. PLoS Biol, 2008 Sep 30. PMID 18828675, Free PMC Article
  5. SMGL-1/NBAS acts as a RAB-8 GEF to regulate unconventional protein secretion. Wang X, et al. J Cell Biol, 2022 Jul 4. PMID 35604368, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables phosphatidylinositol binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in endocytic recycling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in early endosome IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
Sorting nexin-27
NP_492758.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    10543024..10546429
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_060357.6 → NP_492758.1  Sorting nexin-27 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_492758.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q93566
    Conserved Domains (4) summary
    cd06886
    Location:166 → 271
    PX_SNX27; The phosphoinositide binding Phox Homology domain of Sorting Nexin 27
    cd00992
    Location:47 → 139
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13338
    Location:427 → 535
    FERM-like_C_SNX27; Atypical FERM-like domain C-lobe of Sorting nexin 27
    cl00155
    Location:276 → 348
    UBQ; Ubiquitin-like proteins
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools