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ced-12 Cell death abnormality protein 12;ELMO domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 172890, updated on 9-Dec-2024

Summary

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Official Symbol
ced-12
Official Full Name
Cell death abnormality protein 12;ELMO domain-containing protein
Primary source
WormBase:WBGene00000426
Locus tag
CELE_Y106G6E.5
See related
AllianceGenome:WB:WBGene00000426
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables phosphatidylinositol phosphate binding activity; proline-rich region binding activity; and small GTPase binding activity. Involved in several processes, including cytoskeleton organization; engulfment of apoptotic cell; and left/right axis specification. Located in cytoplasm and plasma membrane. Part of guanyl-nucleotide exchange factor complex. Is expressed in intestine; nervous system; reproductive system; and tail. Orthologous to human ELMO1 (engulfment and cell motility 1); ELMO2 (engulfment and cell motility 2); and ELMO3 (engulfment and cell motility 3). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See ced-12 in Genome Data Viewer
Location:
chromosome: I
Exon count:
8
Sequence:
Chromosome: I; NC_003279.8 (10222881..10227009, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene putative 5-formyltetrahydrofolate cyclo-ligase Neighboring gene Casein kinase I gamma Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. CED-5/CED-12 (DOCK/ELMO) can promote and inhibit F-actin formation via distinct motifs that may target different GTPases. Venkatachalam T, et al. PLoS Genet, 2024 Jul. PMID 39083711, Free PMC Article
  2. Cell engulfment, no sooner ced than done. Conradt B. Dev Cell, 2001 Oct. PMID 11703934
  3. C. elegans CED-12 acts in the conserved crkII/DOCK180/Rac pathway to control cell migration and cell corpse engulfment. Wu YC, et al. Dev Cell, 2001 Oct. PMID 11703940
  4. Dock180 and ELMO1 proteins cooperate to promote evolutionarily conserved Rac-dependent cell migration. Grimsley CM, et al. J Biol Chem, 2004 Feb 13. PMID 14638695
  5. Cell biology. Eat me or die. Savill J, et al. Science, 2003 Nov 28. PMID 14645835

See all (65) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CED-5/CED-12 (DOCK/ELMO) can promote and inhibit F-actin formation via distinct motifs that may target different GTPases.
    Title: CED-5/CED-12 (DOCK/ELMO) can promote and inhibit F-actin formation via distinct motifs that may target different GTPases.
  2. Epistatic analyses place mtm-1 upstream of the ternary GEF complex, which consists of ced-2, ced-5 and ced-12, and parallel to mig-2.
    Title: The phosphoinositide phosphatase MTM-1 regulates apoptotic cell corpse clearance through CED-5-CED-12 in C. elegans.
  3. findings suggest that PSR-1 is likely an upstream receptor for the signaling pathway containing CED-2, CED-5, CED-10, and CED-12 proteins and plays an important role in recognizing phosphatidylserine during phagocytosis
    Title: Cell corpse engulfment mediated by C. elegans phosphatidylserine receptor through CED-5 and CED-12.
  4. Rac activation by the ELMO.Dock180 complex at discrete intracellular locations mediated by the N-terminal 330 amino acids of ELMO1 plays a role in cell migration
    Title: Dock180 and ELMO1 proteins cooperate to promote evolutionarily conserved Rac-dependent cell migration.
  5. the PH domain of ELMO binds the Dock180-Rac complex in trans and stabilizes Rac in the nucleotide-free transition state
    Title: PH domain of ELMO functions in trans to regulate Rac activation via Dock180.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables SH3 domain binding IEA
Inferred from Electronic Annotation
more info
  
enables SH3 domain binding TAS
Traceable Author Statement
more info
 PubMed 
enables enzyme binding IPI
Inferred from Physical Interaction
more info
 PubMed 
contributes_to guanyl-nucleotide exchange factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables lipid binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol-3,4,5-trisphosphate binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatidylinositol-3,5-bisphosphate binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatidylinositol-4-phosphate binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables proline-rich region binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-containing complex binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables small GTPase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in actin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in actin filament organization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in apoptotic process involved in development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in apoptotic process involved in development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell motility IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cytoskeletal rearrangement involved in phagocytosis, engulfment IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in engulfment of apoptotic cell IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in establishment of mitotic spindle orientation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in gonad morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in left/right axis specification IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in phagocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in phagocytosis, engulfment IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of distal tip cell migration IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of engulfment of apoptotic cell IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
part_of guanyl-nucleotide exchange factor complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Cell death abnormality protein 12;ELMO domain-containing protein
NP_001293276.1
  • Confirmed by transcript evidence
NP_492693.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    10222881..10227009 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_060292.7 → NP_492693.1  Cell death abnormality protein 12 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_492693.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8STE5
    Conserved Domains (3) summary
    pfam04727
    Location:370 → 465
    ELMO_CED12; ELMO/CED-12 family
    pfam11841
    Location:156 → 304
    DUF3361; Domain of unknown function (DUF3361)
    cl17171
    Location:544 → 679
    PH-like; Pleckstrin homology-like domain

  2. NM_001306347.3 → NP_001293276.1  ELMO domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293276.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    V5Z1T2
    Conserved Domains (3) summary
    pfam04727
    Location:377 → 472
    ELMO_CED12; ELMO/CED-12 family
    pfam11841
    Location:163 → 311
    DUF3361; Domain of unknown function (DUF3361)
    pfam16457
    Location:551 → 686
    PH_12; Pleckstrin homology domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8STE5.1

Gene LinkOut

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