U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

iars-2 isoleucine--tRNA ligase [ Caenorhabditis elegans ]

Gene ID: 172884, updated on 4-Jan-2025

Summary

Go to the top of the page Help
Official Symbol
iars-2
Official Full Name
isoleucine--tRNA ligase
Primary source
WormBase:WBGene00002153
Locus tag
CELE_C25A1.7
See related
AllianceGenome:WB:WBGene00002153
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable isoleucine-tRNA ligase activity. Predicted to be involved in isoleucyl-tRNA aminoacylation and mitochondrial translation. Predicted to be active in mitochondrion. Orthologous to human IARS2 (isoleucyl-tRNA synthetase 2, mitochondrial). [provided by Alliance of Genome Resources, Jan 2025]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See iars-2 in Genome Data Viewer
Location:
chromosome: I
Exon count:
9
Sequence:
Chromosome: I; NC_003279.8 (10180236..10184599)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Fatty acid 2-hydroxylase Neighboring gene Uncharacterized protein Neighboring gene Putative H/ACA ribonucleoprotein complex subunit 3 Neighboring gene Proteasome assembly chaperone 3 Neighboring gene C-type lectin domain-containing protein 87 Neighboring gene Serine/threonine-protein phosphatase 2A regulatory subunit rsa-1 Neighboring gene Nucleolar protein dao-5 Neighboring gene AB hydrolase-1 domain-containing protein;Abhydrolase domain-containing protein lid-1

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. The role of IGF-1 receptor and insulin receptor signaling for the pathogenesis of Alzheimer's disease: from model organisms to human disease. Freude S, et al. Curr Alzheimer Res, 2009 Jun. PMID 19519303
  2. Dynein modifiers in C. elegans: light chains suppress conditional heavy chain mutants. O'Rourke SM, et al. PLoS Genet, 2007 Aug. PMID 17676955, Free PMC Article
  3. Germline Maintenance Through the Multifaceted Activities of GLH/Vasa in Caenorhabditis elegans P Granules. Marnik EA, et al. Genetics, 2019 Nov. PMID 31506335, Free PMC Article
  4. The conserved histone chaperone LIN-53 is required for normal lifespan and maintenance of muscle integrity in Caenorhabditis elegans. Müthel S, et al. Aging Cell, 2019 Dec. PMID 31397537, Free PMC Article
  5. Defect-buffering cellular plasticity increases robustness of metazoan embryogenesis. Xiao L, et al. Cell Syst, 2022 Aug 17. PMID 35882226

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables aminoacyl-tRNA editing activity IEA
Inferred from Electronic Annotation
more info
  
enables aminoacyl-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables isoleucine-tRNA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables isoleucine-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in aminoacyl-tRNA metabolism involved in translational fidelity IEA
Inferred from Electronic Annotation
more info
  
involved_in isoleucyl-tRNA aminoacylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in isoleucyl-tRNA aminoacylation IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrial translation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tRNA aminoacylation for protein translation IEA
Inferred from Electronic Annotation
more info
  
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
isoleucine--tRNA ligase
NP_001251317.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    10180236..10184599
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001264388.5 → NP_001251317.2  isoleucine--tRNA ligase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    E2JL04, Q7Z261
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.