ahr-1 Aryl hydrocarbon receptor protein 1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: ahr-1
Official Full Name: Aryl hydrocarbon receptor protein 1
Primary source: WormBase:WBGene00000096
Locus tag: CELE_C41G7.5
See related: AllianceGenome:WB:WBGene00000096
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables DNA binding activity and RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in negative regulation of locomotion and response to xenobiotic stimulus. Predicted to be part of nuclear aryl hydrocarbon receptor complex. Predicted to be active in nucleus. Is expressed in several structures, including G2; TL.pa; TL.ppp; neurons; and phasmid socket cell. Human ortholog(s) of this gene implicated in retinitis pigmentosa 85. Orthologous to several human genes including AHR (aryl hydrocarbon receptor). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See ahr-1 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 13

Sequence:: Chromosome: I; NC_003279.8 (9522550..9531132)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Involvement of Aryl Hydrocarbon Receptor in Longevity and Healthspan: Insights from Humans, Mice, and C. elegans.
Title: Involvement of Aryl Hydrocarbon Receptor in Longevity and Healthspan: Insights from Humans, Mice, and C. elegans.
Dietary and environmental factors have opposite AhR-dependent effects on C. elegans healthspan.
Title: Dietary and environmental factors have opposite AhR-dependent effects on C. elegans healthspan.
These results extend previous studies demonstrating control of gcy family gene expression by AHR-1, and furthermore suggest a role of AHR-1 in regulation of a neuropeptide gene as well as pseudogenes.
Title: Transcriptional profiling reveals differential expression of a neuropeptide-like protein and pseudogenes in aryl hydrocarbon receptor-1 mutant Caenorhabditis elegans.
aha-1 and ahr-1 act genetically upstream of cam-1. CAM-1, a membrane-bound receptor tyrosine kinase, is present on both BDU and PLM cells and likely serves as a Wnt antagonist
Title: Neuronal target identification requires AHA-1-mediated fine-tuning of Wnt signaling in C. elegans.
Fatty acid composition and gene expression profiles are altered in ahr-1 mutant.
Title: Fatty acid composition and gene expression profiles are altered in aryl hydrocarbon receptor-1 mutant Caenorhabditis elegans.
We conclude that the AHR-1:AHA-1 transcription complex regulates the expression of soluble guanylate cyclase genes and other unidentified genes that are essential for acute regulation of aggregation behavior.
Title: The Caenorhabditis elegans AHR-1 transcription complex controls expression of soluble guanylate cyclase genes in the URX neurons and regulates aggregation behavior.
Results suggest that the aryl hydrocarbon receptor-1 transcriptional complex acts in combination with other intrinsic and extracellular factors to direct the differentiation of distinct neuronal subtypes.
Title: The Caenorhabditis elegans aryl hydrocarbon receptor, AHR-1, regulates neuronal development.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C41G7.6 (e-PCR)
- UniSTS:317998

C41G7.5 (e-PCR)
- UniSTS:313846

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables nuclear receptor activity	IBA Inferred from Biological aspect of Ancestor more info
contributes_to nuclear receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info
enables protein heterodimerization activity	ISS Inferred from Sequence or Structural Similarity more info
enables sequence-specific double-stranded DNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables transcription cis-regulatory region binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in behavior	IEA Inferred from Electronic Annotation more info
involved_in intracellular receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in intracellular receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of locomotion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nervous system development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to chemical	IEA Inferred from Electronic Annotation more info
involved_in response to xenobiotic stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in response to xenobiotic stimulus	IEA Inferred from Electronic Annotation more info
involved_in xenobiotic metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of aryl hydrocarbon receptor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of nuclear aryl hydrocarbon receptor complex	ISS Inferred from Sequence or Structural Similarity more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: Aryl hydrocarbon receptor protein 1

NP_001021036.1

Confirmed by transcript evidence

NP_001021037.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

9522550..9531132

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001025865.4 → NP_001021036.1 Aryl hydrocarbon receptor protein 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001021036.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O44712, Q564W4, Q93369

Conserved Domains (4) summary

cd00083
Location:28 → 69

HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...

cd00130
Location:137 → 195

PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...

pfam00989
Location:136 → 235

PAS; PAS fold

pfam08447
Location:298 → 378

PAS_3; PAS fold
NM_001025866.5 → NP_001021037.1 Aryl hydrocarbon receptor protein 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001021037.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O44712

Conserved Domains (3) summary

cd00130
Location:95 → 153

PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...

pfam00989
Location:94 → 193

PAS; PAS fold

pfam08447
Location:256 → 336

PAS_3; PAS fold