U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

calm-1 EF-hand domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 172774, updated on 4-Jan-2025

Summary

Go to the top of the page Help
Official Symbol
calm-1
Official Full Name
EF-hand domain-containing protein
Primary source
WormBase:WBGene00009260
Locus tag
CELE_F30A10.1
See related
AllianceGenome:WB:WBGene00009260
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable calcium ion binding activity and magnesium ion binding activity. Predicted to be involved in calcium ion homeostasis. Is expressed in body wall musculature; cholinergic neurons; and ventral nerve cord. Human ortholog(s) of this gene implicated in Usher syndrome type 1J and autosomal recessive nonsyndromic deafness 48. Orthologous to human CIB2 (calcium and integrin binding family member 2) and CIB3 (calcium and integrin binding family member 3). [provided by Alliance of Genome Resources, Jan 2025]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See calm-1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
4
Sequence:
Chromosome: I; NC_003279.8 (9472642..9474801, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Skp1-related protein Neighboring gene Skp1-related protein Neighboring gene Saposin B-type domain-containing protein Neighboring gene Saposin B-type domain-containing protein

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. The structure of the Caenorhabditis elegans TMC-2 complex suggests roles of lipid-mediated subunit contacts in mechanosensory transduction. Clark S, et al. Proc Natl Acad Sci U S A, 2024 Feb 20. PMID 38354260, Free PMC Article
  2. Structures of the TMC-1 complex illuminate mechanosensory transduction. Jeong H, et al. Nature, 2022 Oct. PMID 36224384, Free PMC Article
  3. Localized sphingolipid signaling at presynaptic terminals is regulated by calcium influx and promotes recruitment of priming factors. Chan JP, et al. J Neurosci, 2012 Dec 5. PMID 23223309, Free PMC Article
  4. Defect-buffering cellular plasticity increases robustness of metazoan embryogenesis. Xiao L, et al. Cell Syst, 2022 Aug 17. PMID 35882226
  5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in calcium ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
EF-hand domain-containing protein
NP_492514.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    9472642..9474801 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_060113.5 → NP_492514.2  EF-hand domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_492514.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q93640
    Conserved Domains (2) summary
    COG5126
    Location:32 → 192
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    cl08302
    Location:121 → 183
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools