F26H9.5 putative phosphoserine aminotransferase [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: F26H9.5
Official Full Name: putative phosphoserine aminotransferase
Primary source: WormBase:WBGene00009177
Locus tag: CELE_F26H9.5
See related: AllianceGenome:WB:WBGene00009177
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable O-phospho-L-serine:2-oxoglutarate aminotransferase activity and pyridoxal phosphate binding activity. Predicted to be involved in L-serine biosynthetic process. Predicted to be active in cytoplasm. Is expressed in head; intestine; and tail. Human ortholog(s) of this gene implicated in Neu-Laxova syndrome 2 and PSAT deficiency. Orthologous to human PSAT1 (phosphoserine aminotransferase 1). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See F26H9.5 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 5

Sequence:: Chromosome: I; NC_003279.8 (9312635..9314488, complement)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F26H9.5 (e-PCR)
- UniSTS:321411

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables O-phospho-L-serine:2-oxoglutarate aminotransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables O-phospho-L-serine:2-oxoglutarate aminotransferase activity	IEA Inferred from Electronic Annotation more info
enables pyridoxal phosphate binding	IBA Inferred from Biological aspect of Ancestor more info
enables transaminase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in L-serine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in L-serine biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in L-serine metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: putative phosphoserine aminotransferase

NP_492483.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

9312635..9314488 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_060082.8 → NP_492483.1 putative phosphoserine aminotransferase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_492483.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P91856

Conserved Domains (2) summary

cd00611
Location:8 → 365

PSAT_like; Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as ...

COG1932
Location:6 → 367

SerC; Phosphoserine aminotransferase [Coenzyme transport and metabolism, Amino acid transport and metabolism]