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phac-1 Phosphatase and actin regulator 2 [ Caenorhabditis elegans ]

Gene ID: 172753, updated on 4-Jan-2025

Summary

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Official Symbol
phac-1
Official Full Name
Phosphatase and actin regulator 2
Primary source
WormBase:WBGene00009174
Locus tag
CELE_F26H9.2
See related
AllianceGenome:WB:WBGene00009174
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable actin binding activity. Predicted to be involved in actin cytoskeleton organization. Is expressed in excretory cell; nervous system; and rectal epithelium. Human ortholog(s) of this gene implicated in Parkinson's disease; artery disease (multiple); brain disease (multiple); and multiple sclerosis. Orthologous to several human genes including PHACTR4 (phosphatase and actin regulator 4). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See phac-1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
9
Sequence:
Chromosome: I; NC_003279.8 (9289744..9294042, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Phosphotransferase Neighboring gene DNA-directed RNA polymerase I subunit RPA2 homolog Neighboring gene DUF305 domain-containing protein;F-box domain-containing protein Neighboring gene Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2 Neighboring gene small monomeric GTPase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cortical domain correction repositions the polarity boundary to match the cytokinesis furrow in C. elegans embryos. Schenk C, et al. Development, 2010 May. PMID 20430749, Free PMC Article
  2. A gateway-compatible yeast one-hybrid system. Deplancke B, et al. Genome Res, 2004 Oct. PMID 15489331, Free PMC Article
  3. Defect-buffering cellular plasticity increases robustness of metazoan embryogenesis. Xiao L, et al. Cell Syst, 2022 Aug 17. PMID 35882226
  4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables actin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Phosphatase and actin regulator 2
NP_001412553.1
  • Confirmed by transcript evidence
NP_001412554.1
  • Confirmed by transcript evidence
NP_001417602.1
  • Confirmed by transcript evidence
NP_001417603.1
  • Confirmed by transcript evidence
NP_001417604.1
  • Confirmed by transcript evidence
NP_492478.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    9289744..9294042 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001430669.1 → NP_001417603.1  Phosphatase and actin regulator 2 [Caenorhabditis elegans]

    Status: REVIEWED

  2. NM_060077.7 → NP_492478.2  Phosphatase and actin regulator 2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_492478.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    P91855
    Conserved Domains (1) summary
    smart00707
    Location:392 → 415
    RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2

  3. NM_001430671.1 → NP_001417604.1  Phosphatase and actin regulator 2 [Caenorhabditis elegans]

    Status: REVIEWED

  4. NM_001430670.1 → NP_001417602.1  Phosphatase and actin regulator 2 [Caenorhabditis elegans]

    Status: REVIEWED

  5. NM_001425624.1 → NP_001412553.1  Phosphatase and actin regulator 2 [Caenorhabditis elegans]

    Status: REVIEWED

  6. NM_001425625.1 → NP_001412554.1  Phosphatase and actin regulator 2 [Caenorhabditis elegans]

    Status: REVIEWED

Nucleotide Protein
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