tat-5 Phospholipid-transporting ATPase;putative phospholipid-transporting ATPase tat-5 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: tat-5
Official Full Name: Phospholipid-transporting ATPase;putative phospholipid-transporting ATPase tat-5
Primary source: WormBase:WBGene00009498
Locus tag: CELE_F36H2.1
See related: AllianceGenome:WB:WBGene00009498
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable ATPase-coupled intramembrane lipid transporter activity. Involved in embryo development. Located in cytoplasmic vesicle and plasma membrane. Is expressed widely. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with poor growth and behavioral abnormalities. Orthologous to several human genes including ATP9B (ATPase phospholipid transporting 9B (putative)). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See tat-5 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 12

Sequence:: Chromosome: I; NC_003279.8 (9234170..9245926, complement)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TAT-5 provides a potential molecular link between loss of phosphatidylethanolamine asymmetry and the dynamic budding of vesicles from the plasma membrane, supporting the hypothesis that lipid asymmetry regulates budding.
Title: The P4-ATPase TAT-5 inhibits the budding of extracellular vesicles in C. elegans embryos.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F36H2.1 (e-PCR)
- UniSTS:307611

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATPase-coupled intramembrane lipid transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATPase-coupled intramembrane lipid transporter activity	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables transporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in embryo development ending in birth or egg hatching	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in lipid transport	IEA Inferred from Electronic Annotation more info
involved_in phospholipid translocation	IBA Inferred from Biological aspect of Ancestor more info
involved_in phospholipid transport	IEA Inferred from Electronic Annotation more info
involved_in reproductive process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasmic vesicle	IDA Inferred from Direct Assay more info	PubMed
is_active_in endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in trans-Golgi network	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Phospholipid-transporting ATPase;putative phospholipid-transporting ATPase tat-5

NP_001021457.1

Confirmed by transcript evidence

NP_001021458.2

Confirmed by transcript evidence

NP_001040665.1

Confirmed by transcript evidence

NP_001382693.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

9234170..9245926 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001026286.6 → NP_001021457.1 putative phospholipid-transporting ATPase tat-5 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001021457.1

Status: REVIEWED

UniProtKB/Swiss-Prot

G5EBH1, G5EE81, G5EGE0

Conserved Domains (2) summary

cd07541
Location:105 → 995

P-type_ATPase_APLT_Neo1-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Neo1p and human putative APLT, ATP9B

pfam13246
Location:501 → 600

Cation_ATPase; Cation transport ATPase (P-type)
NM_001026287.7 → NP_001021458.2 putative phospholipid-transporting ATPase tat-5 [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (2) summary

cd07541
Location:87 → 977

P-type_ATPase_APLT_Neo1-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Neo1p and human putative APLT, ATP9B

pfam13246
Location:484 → 582

Cation_ATPase; Cation transport ATPase (P-type)
NM_001047200.3 → NP_001040665.1 putative phospholipid-transporting ATPase tat-5 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001040665.1

Status: REVIEWED

UniProtKB/TrEMBL

G5EE81

Conserved Domains (6) summary

TIGR01652
Location:100 → 1070

ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase

pfam00122
Location:158 → 397

E1-E2_ATPase; E1-E2 ATPase

pfam13246
Location:499 → 597

Cation_ATPase; Cation transport ATPase (P-type)

pfam16209
Location:100 → 151

PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal

pfam16212
Location:836 → 1064

PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal

cl21460
Location:789 → 831

HAD_like; Haloacid Dehalogenase-like Hydrolases
NM_001395788.1 → NP_001382693.1 Phospholipid-transporting ATPase [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A7I9BBC6

Conserved Domains (2) summary

cd07541
Location:90 → 980

P-type_ATPase_APLT_Neo1-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Neo1p and human putative APLT, ATP9B

pfam13246
Location:486 → 585

Cation_ATPase; Cation transport ATPase (P-type)