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fcp-1 RNA polymerase II subunit A C-terminal domain phosphatase [ Caenorhabditis elegans ]

Gene ID: 172719, updated on 4-Jan-2025

Summary

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Official Symbol
fcp-1
Official Full Name
RNA polymerase II subunit A C-terminal domain phosphatase
Primary source
WormBase:WBGene00009479
Locus tag
CELE_F36F2.6
See related
AllianceGenome:WB:WBGene00009479
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables RNA polymerase II CTD heptapeptide repeat phosphatase activity. Involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Orthologous to human CTDP1 (CTD phosphatase subunit 1). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See fcp-1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
9
Sequence:
Chromosome: I; NC_003279.8 (9004513..9008708, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene t-SNARE coiled-coil homology domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene E3 ubiquitin-protein ligase RBBP6 Neighboring gene EB domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Transcription reactivation steps stimulated by oocyte maturation in C. elegans. Walker AK, et al. Dev Biol, 2007 Apr 1. PMID 17291483, Free PMC Article
  2. A novel protein phosphatase is a binding partner for the protein kinase domains of UNC-89 (Obscurin) in Caenorhabditis elegans. Qadota H, et al. Mol Biol Cell, 2008 Jun. PMID 18337465, Free PMC Article
  3. Phosphorylation of RNA polymerase II is independent of P-TEFb in the C. elegans germline. Bowman EA, et al. Development, 2013 Sep. PMID 23903194, Free PMC Article
  4. Defect-buffering cellular plasticity increases robustness of metazoan embryogenesis. Xiao L, et al. Cell Syst, 2022 Aug 17. PMID 35882226
  5. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables RNA polymerase II CTD heptapeptide repeat phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II CTD heptapeptide repeat phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II CTD heptapeptide repeat phosphatase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables myosin phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in oogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
RNA polymerase II subunit A C-terminal domain phosphatase
NP_492423.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    9004513..9008708 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_060022.5 → NP_492423.2  RNA polymerase II subunit A C-terminal domain phosphatase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_492423.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q95QG8
    Conserved Domains (2) summary
    cd00027
    Location:358 → 431
    BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...
    cl21460
    Location:138 → 284
    HAD_like; Haloacid Dehalogenase-like Hydrolases
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q95QG8.2

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