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thoc-3 WD_REPEATS_REGION domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 172713, updated on 2-Nov-2024

Summary

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Official Symbol
thoc-3
Official Full Name
WD_REPEATS_REGION domain-containing protein
Primary source
WormBase:WBGene00009341
Locus tag
CELE_F32H2.4
See related
AllianceGenome:WB:WBGene00009341
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to be involved in mRNA export from nucleus. Predicted to be part of THO complex part of transcription export complex. Orthologous to human THOC3 (THO complex subunit 3). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See thoc-3 in Genome Data Viewer
Location:
chromosome: I
Exon count:
6
Sequence:
Chromosome: I; NC_003279.8 (8971139..8973037)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Mediator of RNA polymerase II transcription subunit 31 Neighboring gene Spindle-defective protein 2 Neighboring gene Integrator complex subunit 1 R4 domain-containing protein Neighboring gene SRCR domain-containing protein Neighboring gene ncRNA Neighboring gene Fatty acid synthase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Caenorhabditis elegans THO complex is required for the mitotic cell cycle and development. Castellano-Pozo M, et al. PLoS One, 2012. PMID 23285047, Free PMC Article
  2. PUF-8 and TCER-1 are essential for normal levels of multiple mRNAs in the C. elegans germline. Pushpa K, et al. Development, 2013 Mar. PMID 23444359, Free PMC Article
  3. Defect-buffering cellular plasticity increases robustness of metazoan embryogenesis. Xiao L, et al. Cell Syst, 2022 Aug 17. PMID 35882226
  4. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
  5. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in mRNA export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mRNA export from nucleus IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of THO complex ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
part_of THO complex part of transcription export complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
WD_REPEATS_REGION domain-containing protein
NP_492416.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    8971139..8973037
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_060015.6 → NP_492416.2  WD_REPEATS_REGION domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_492416.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    P91867
    Conserved Domains (2) summary
    sd00039
    Location:39 → 78
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:41 → 313
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
Nucleotide Protein
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