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hbs-1 Tr-type G domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 172672, updated on 4-Jan-2025

Summary

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Official Symbol
hbs-1
Official Full Name
Tr-type G domain-containing protein
Primary source
WormBase:WBGene00010622
Locus tag
CELE_K07A12.4
See related
AllianceGenome:WB:WBGene00010622
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable GTPase activity. Predicted to be involved in translation. Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in beta thalassemia. Orthologous to human HBS1L (HBS1 like translational GTPase). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See hbs-1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
12
Sequence:
Chromosome: I; NC_003279.8 (8687634..8690937, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Leucine-rich repeat-containing protein egg-6 Neighboring gene ncRNA Neighboring gene Homolog of Odr-2 (Two) Neighboring gene Small ribosomal subunit protein uS15m Neighboring gene MBD domain-containing protein;Pre-mRNA-splicing factor SLU7;Pre-mRNA-splicing factor SYF2 Neighboring gene putative ATP synthase subunit g 1, mitochondrial

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Ubiquitination of stalled ribosomes enables mRNA decay via HBS-1 and NONU-1 in vivo. Monem PC, et al. PLoS Genet, 2023 Jan. PMID 36626369, Free PMC Article
  2. RNA targets and specificity of Staufen, a double-stranded RNA-binding protein in Caenorhabditis elegans. LeGendre JB, et al. J Biol Chem, 2013 Jan 25. PMID 23195953, Free PMC Article
  3. Defect-buffering cellular plasticity increases robustness of metazoan embryogenesis. Xiao L, et al. Cell Syst, 2022 Aug 17. PMID 35882226
  4. Depletion of endogenously biotinylated carboxylases enhances the sensitivity of TurboID-mediated proximity labeling in Caenorhabditis elegans. Artan M, et al. J Biol Chem, 2022 Sep. PMID 35933017, Free PMC Article
  5. Interactome analysis of Caenorhabditis elegans synapses by TurboID-based proximity labeling. Artan M, et al. J Biol Chem, 2021 Sep. PMID 34416233, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in translation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Tr-type G domain-containing protein
NP_001021555.2
  • Confirmed by transcript evidence
NP_001021556.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    8687634..8690937 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001026384.6 → NP_001021555.2  Tr-type G domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001021555.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    P90922
    Conserved Domains (1) summary
    COG5256
    Location:176 → 606
    TEF1; Translation elongation factor EF-1alpha (GTPase) [Translation, ribosomal structure and biogenesis]

  2. NM_001026385.6 → NP_001021556.2  Tr-type G domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001021556.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q564V6
    Conserved Domains (1) summary
    COG5256
    Location:158 → 588
    TEF1; Translation elongation factor EF-1alpha (GTPase) [Translation, ribosomal structure and biogenesis]
Nucleotide Protein
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