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syx-17 t-SNARE coiled-coil homology domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 172663, updated on 4-Jan-2025

Summary

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Official Symbol
syx-17
Official Full Name
t-SNARE coiled-coil homology domain-containing protein
Primary source
WormBase:WBGene00012150
Locus tag
CELE_VF39H2L.1
See related
AllianceGenome:WB:WBGene00012150
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable SNAP receptor activity and SNARE binding activity. Predicted to be involved in intracellular protein transport; vesicle docking; and vesicle fusion. Predicted to be located in membrane. Predicted to be part of SNARE complex. Predicted to be active in synaptic vesicle. Orthologous to human STX17 (syntaxin 17). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See syx-17 in Genome Data Viewer
Location:
chromosome: I
Exon count:
6
Sequence:
Chromosome: I; NC_003279.8 (8644460..8646304)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Microfibrillar-associated protein 1 Neighboring gene GCF C-terminal domain-containing protein Neighboring gene Peptidyl-prolyl cis-trans isomerase sig-7 Neighboring gene SPSAKWMRF-amide 3

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. MitoSNARE Assembly and Disassembly Factors Regulate Basal Autophagy and Aging in C. elegans. Gkikas I, et al. Int J Mol Sci, 2023 Feb 20. PMID 36835643, Free PMC Article
  2. Caenorhabditis elegans SNAP-29 is required for organellar integrity of the endomembrane system and general exocytosis in intestinal epithelial cells. Sato M, et al. Mol Biol Cell, 2011 Jul 15. PMID 21613542, Free PMC Article
  3. Depletion of syntaxins in the early Caenorhabditis elegans embryo reveals a role for membrane fusion events in cytokinesis. Jantsch-Plunger V, et al. Curr Biol, 1999 Jul 15. PMID 10421575
  4. The SM protein VPS-45 is required for RAB-5-dependent endocytic transport in Caenorhabditis elegans. Gengyo-Ando K, et al. EMBO Rep, 2007 Feb. PMID 17235359, Free PMC Article
  5. Molecular Basis of Neuronal Autophagy in Ageing: Insights from Caenorhabditis elegans. Konstantinidis G, et al. Cells, 2021 Mar 21. PMID 33800981, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables SNAP receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables SNARE binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vesicle docking IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vesicle fusion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of SNARE complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in synaptic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
t-SNARE coiled-coil homology domain-containing protein
NP_492342.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    8644460..8646304
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_059941.4 → NP_492342.1  t-SNARE coiled-coil homology domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_492342.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O62387
    Conserved Domains (1) summary
    cl22856
    Location:132 → 188
    SNARE; SNARE motif
Nucleotide Protein
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