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R05D11.9 Sphingomyelin phosphodiesterase 4 [ Caenorhabditis elegans ]

Gene ID: 172650, updated on 9-Dec-2024

Summary

Official Symbol
R05D11.9
Official Full Name
Sphingomyelin phosphodiesterase 4
Primary source
WormBase:WBGene00011037
Locus tag
CELE_R05D11.9
See related
AllianceGenome:WB:WBGene00011037
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable sphingomyelin phosphodiesterase D activity. Predicted to be involved in ceramide biosynthetic process; glycerophospholipid catabolic process; and sphingomyelin catabolic process. Predicted to be located in endoplasmic reticulum and trans-Golgi network. Orthologous to human SMPD4 (sphingomyelin phosphodiesterase 4). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

See R05D11.9 in Genome Data Viewer
Location:
chromosome: I
Exon count:
11
Sequence:
Chromosome: I; NC_003279.8 (8593027..8596225)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene putative nuclear transport factor 2 Neighboring gene Transmembrane protein 208 Neighboring gene Partner of xrn-2 protein 1 Neighboring gene putative ATP-dependent RNA helicase DDX52

General gene information

Markers

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables sphingomyelin phosphodiesterase D activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables sphingomyelin phosphodiesterase D activity IEA
Inferred from Electronic Annotation
more info
 
enables sphingomyelin phosphodiesterase D activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Process Evidence Code Pubs
involved_in ceramide biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in glycerophospholipid catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in sphingomyelin catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in sphingomyelin catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
located_in endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in trans-Golgi network ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 

General protein information

Preferred Names
Sphingomyelin phosphodiesterase 4
NP_492324.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    8593027..8596225
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_059923.10NP_492324.2  Sphingomyelin phosphodiesterase 4 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_492324.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95ZR2
    Conserved Domains (1) summary
    pfam14724
    Location:479562
    mit_SMPDase; Mitochondrial-associated sphingomyelin phosphodiesterase