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sin-3 Paired amphipathic helix protein sin-3 [ Caenorhabditis elegans ]

Gene ID: 172628, updated on 2-Nov-2024

Summary

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Official Symbol
sin-3
Official Full Name
Paired amphipathic helix protein sin-3
Primary source
WormBase:WBGene00004117
Locus tag
CELE_F02E9.4
See related
AllianceGenome:WB:WBGene00004117
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Contributes to histone deacetylase activity. Involved in several processes, including cell fate specification; nematode male tail mating organ morphogenesis; and vulval development. Acts upstream of or within defense response to other organism and response to endoplasmic reticulum stress. Predicted to be located in chromatin. Predicted to be part of Sin3-type complex. Is expressed in excretory cell; intestine; nervous system; pharynx; and ray structural cell. Human ortholog(s) of this gene implicated in chromosome 15q24 deletion syndrome. Orthologous to human SIN3A (SIN3 transcription regulator family member A) and SIN3B (SIN3 transcription regulator family member B). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See sin-3 in Genome Data Viewer
Location:
chromosome: I
Exon count:
20
Sequence:
Chromosome: I; NC_003279.8 (8416816..8425051)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Protein yippee-like Neighboring gene Protein lin-28 Neighboring gene Tartrate-resistant acid phosphatase type 5 Neighboring gene Oxidative stress-responsive serine-rich protein 1 Neighboring gene WD_REPEATS_REGION domain-containing protein Neighboring gene Dipeptidyl peptidase 3 Neighboring gene pseudo

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. SIN-3 transcriptional coregulator maintains mitochondrial homeostasis and polyamine flux. Giovannetti M, et al. iScience, 2024 May 17. PMID 38746662, Free PMC Article
  2. ROS is the major player in regulating altered autophagy and lifespan in sin-3 mutants of C. elegans. Sharma M, et al. Autophagy, 2018. PMID 29912629, Free PMC Article
  3. SIN-3 as a key determinant of lifespan and its sex dependent differential role on healthspan in Caenorhabditis elegans. Pandey R, et al. Aging (Albany NY), 2018 Dec 12. PMID 30541942, Free PMC Article
  4. Understanding Longevity: SIN-3 and DAF-16 Revealed as Independent Players in Lifespan Regulation. Konwar C, et al. J Gerontol A Biol Sci Med Sci, 2024 Sep 1. PMID 38894529
  5. Physical and functional interaction between SET1/COMPASS complex component CFP-1 and a Sin3S HDAC complex in C. elegans. Beurton F, et al. Nucleic Acids Res, 2019 Dec 2. PMID 31602465, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Understanding Longevity: SIN-3 and DAF-16 Revealed as Independent Players in Lifespan Regulation.
    Title: Understanding Longevity: SIN-3 and DAF-16 Revealed as Independent Players in Lifespan Regulation.
  2. SIN-3 acts in distinct complexes to regulate the germline transcriptional program in Caenorhabditis elegans.
    Title: SIN-3 acts in distinct complexes to regulate the germline transcriptional program in Caenorhabditis elegans.
  3. Overlapping and non-overlapping roles of the class-I histone deacetylase-1 corepressors LET-418, SIN-3, and SPR-1 in Caenorhabditis elegans embryonic development.
    Title: Overlapping and non-overlapping roles of the class-I histone deacetylase-1 corepressors LET-418, SIN-3, and SPR-1 in Caenorhabditis elegans embryonic development.
  4. The results suggest that genetic perturbation along with the gender play an important role in determining the lifespan, healthspan and overall fitness of an organism.
    Title: SIN-3 as a key determinant of lifespan and its sex dependent differential role on healthspan in Caenorhabditis elegans.
  5. SIN-3 differentially modulates autophagy and lifespan.
    Title: ROS is the major player in regulating altered autophagy and lifespan in sin-3 mutants of C. elegans.
  6. SIN-3 and its associated HDAC corepressor complex act as mediators of male sensory ray development
    Title: C. elegans SIN-3 and its associated HDAC corepressor complex act as mediators of male sensory ray development.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
contributes_to histone deacetylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription corepressor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell fate specification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within defense response to other organism IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in locomotion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nematode male tail mating organ morphogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in nematode male tail mating organ morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within response to endoplasmic reticulum stress IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in vulval development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of Sin3-type complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Paired amphipathic helix protein sin-3
NP_001122442.1
  • Confirmed by transcript evidence
NP_492284.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    8416816..8425051
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_059883.8 → NP_492284.2  Paired amphipathic helix protein sin-3 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_492284.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A5JYW9
    Conserved Domains (4) summary
    smart00761
    Location:801 → 900
    HDAC_interact; Histone deacetylase (HDAC) interacting
    COG5602
    Location:271 → 1065
    Sin3; Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics]
    pfam02671
    Location:306 → 349
    PAH; Paired amphipathic helix repeat
    pfam16879
    Location:1144 → 1339
    Sin3a_C; C-terminal domain of Sin3a protein

  2. NM_001128970.5 → NP_001122442.1  Paired amphipathic helix protein sin-3 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001122442.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A5JYW9, O01319
    Conserved Domains (4) summary
    smart00761
    Location:801 → 900
    HDAC_interact; Histone deacetylase (HDAC) interacting
    COG5602
    Location:271 → 1062
    Sin3; Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics]
    pfam02671
    Location:306 → 349
    PAH; Paired amphipathic helix repeat
    pfam16879
    Location:1146 → 1341
    Sin3a_C; C-terminal domain of Sin3a protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A5JYW9.1

Gene LinkOut

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