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abts-1 Anion exchange protein [ Caenorhabditis elegans ]

Gene ID: 172613, updated on 9-Dec-2024

Summary

Official Symbol
abts-1
Official Full Name
Anion exchange protein
Primary source
WormBase:WBGene00009920
Locus tag
CELE_F52B5.1
See related
AllianceGenome:WB:WBGene00009920
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables chloride transmembrane transporter activity and solute:inorganic anion antiporter activity. Involved in several processes, including cholinergic synaptic transmission; regulation of GABAergic synaptic transmission; and response to serotonin. Predicted to be located in basolateral plasma membrane; lateral plasma membrane; and synapse. Predicted to be active in plasma membrane. Is expressed in several structures, including hypodermis; intestine; nervous system; pharynx; and reproductive system. Human ortholog(s) of this gene implicated in renal tubular acidosis. Orthologous to several human genes including SLC4A10 (solute carrier family 4 member 10); SLC4A7 (solute carrier family 4 member 7); and SLC4A8 (solute carrier family 4 member 8). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

See abts-1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
12
Sequence:
Chromosome: I; NC_003279.8 (8296917..8307566, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Casein kinase II subunit beta Neighboring gene Nuclear pore complex protein Nup85 Neighboring gene Meiotic spindle formation protein mei-1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in bicarbonate transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in chloride transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in inorganic anion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in monoatomic anion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in monoatomic anion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of intracellular pH IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of synaptic transmission, GABAergic IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in response to arsenic-containing substance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to serotonin IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in sodium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in synaptic transmission, cholinergic IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in basolateral plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in lateral plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IC
Inferred by Curator
more info
PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
Anion exchange protein
NP_001129776.1
  • Confirmed by transcript evidence
NP_001366789.1
  • Confirmed by transcript evidence
NP_001367194.1
  • Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    8296917..8307566 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001136304.5NP_001129776.1  Anion exchange protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001129776.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EDF4, O61304
    Conserved Domains (3) summary
    TIGR00834
    Location:861049
    ae; anion exchange protein
    pfam00955
    Location:437952
    HCO3_cotransp; HCO3- transporter family
    pfam07565
    Location:109387
    Band_3_cyto; Band 3 cytoplasmic domain
  2. NM_001380825.2NP_001366789.1  Anion exchange protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EC65, O61304
    Conserved Domains (1) summary
    TIGR00834
    Location:441007
    ae; anion exchange protein
  3. NM_001380826.1NP_001367194.1  Anion exchange protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    B3WFV9, O61304
    Conserved Domains (1) summary
    TIGR00834
    Location:861103
    ae; anion exchange protein