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npp-2 Nuclear pore complex protein Nup85 [ Caenorhabditis elegans ]

Gene ID: 172611, updated on 4-Jan-2025

Summary

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Official Symbol
npp-2
Official Full Name
Nuclear pore complex protein Nup85
Primary source
WormBase:WBGene00003788
Locus tag
CELE_T01G9.4
See related
AllianceGenome:WB:WBGene00003788
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to be a structural constituent of nuclear pore. Involved in embryo development; nucleus organization; and protein localization to organelle. Part of nuclear pore. Human ortholog(s) of this gene implicated in nephrotic syndrome type 17. Orthologous to human NUP85 (nucleoporin 85). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See npp-2 in Genome Data Viewer
Location:
chromosome: I
Exon count:
6
Sequence:
Chromosome: I; NC_003279.8 (8291299..8293640, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene PHAF1 protein T01G9.2 Neighboring gene LRRCT domain-containing protein Neighboring gene Casein kinase II subunit beta Neighboring gene Meiotic spindle formation protein mei-1 Neighboring gene Anion exchange protein Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. X-chromosome silencing in the germline of C. elegans. Kelly WG, et al. Development, 2002 Jan. PMID 11807039, Free PMC Article
  2. mei-1, a gene required for meiotic spindle formation in Caenorhabditis elegans, is a member of a family of ATPases. Clark-Maguire S, et al. Genetics, 1994 Feb. PMID 8150281, Free PMC Article
  3. Dissection of the NUP107 nuclear pore subcomplex reveals a novel interaction with spindle assembly checkpoint protein MAD1 in Caenorhabditis elegans. Ródenas E, et al. Mol Biol Cell, 2012 Mar. PMID 22238360, Free PMC Article
  4. A broad requirement for TLS polymerases η and κ, and interacting sumoylation and nuclear pore proteins, in lesion bypass during C. elegans embryogenesis. Roerink SF, et al. PLoS Genet, 2012 Jun. PMID 22761594, Free PMC Article
  5. Operons in C. elegans: polycistronic mRNA precursors are processed by trans-splicing of SL2 to downstream coding regions. Spieth J, et al. Cell, 1993 May 7. PMID 8098272

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables structural constituent of nuclear pore IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of nuclear pore IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in embryo development ending in birth or egg hatching IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mRNA export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mRNA transport IEA
Inferred from Electronic Annotation
more info
  
involved_in nucleus organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein import into nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein localization to kinetochore IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization to nuclear envelope IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear membrane IEA
Inferred from Electronic Annotation
more info
  
part_of nuclear pore IEA
Inferred from Electronic Annotation
more info
  
part_of nuclear pore IMP
Inferred from Mutant Phenotype
more info
 PubMed 
part_of nuclear pore outer ring IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Nuclear pore complex protein Nup85
NP_492256.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    8291299..8293640 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_059855.7 → NP_492256.1  Nuclear pore complex protein Nup85 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_492256.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q22078
    Conserved Domains (1) summary
    pfam07575
    Location:35 → 559
    Nucleopor_Nup85; Nup85 Nucleoporin
Nucleotide Protein
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