lin-10 Protein lin-10 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: lin-10
Official Full Name: Protein lin-10
Primary source: WormBase:WBGene00002999
Locus tag: CELE_C09H6.2
See related: AllianceGenome:WB:WBGene00002999
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables small GTPase binding activity. Involved in several processes, including neuron-neuron synaptic transmission; positive regulation of backward locomotion; and positive regulation of vulval development. Located in several cellular components, including Golgi trans cisterna; neuronal cell body; and trans-Golgi network transport vesicle. Is expressed in several structures, including hypodermis; nervous system; reproductive system; somatic gonad precursor; and vulval precursor cell. Orthologous to several human genes including APBA1 (amyloid beta precursor protein binding family A member 1) and APBA2 (amyloid beta precursor protein binding family A member 2). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See lin-10 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 16

Sequence:: Chromosome: I; NC_003279.8 (8109746..8119316, complement)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

LIN-10 can promote LET-23 EGFR signaling and trafficking independently of LIN-2 and LIN-7.
Title: LIN-10 can promote LET-23 EGFR signaling and trafficking independently of LIN-2 and LIN-7.
LIN-10 uses distinct modular domains for its functions in neurons and epithelial cells
Title: Distinct LIN-10 domains are required for its neuronal function, its epithelial function, and its synaptic localization.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C09H6.2 (e-PCR)
- UniSTS:309030

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables small GTPase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
involved_in nervous system development	IEA Inferred from Electronic Annotation more info
involved_in neuron-neuron synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of backward locomotion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of vulval development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization	IDA Inferred from Direct Assay more info	PubMed
involved_in protein localization to basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in protein localization to early endosome	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in receptor localization to synapse	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of backward locomotion	IGI Inferred from Genetic Interaction more info	PubMed
involved_in response to mechanical stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sensory perception of touch	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	IMP Inferred from Mutant Phenotype more info	PubMed
located_in Golgi cisterna membrane	IEA Inferred from Electronic Annotation more info
located_in Golgi trans cisterna	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
is_active_in dendritic spine	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in neuron projection	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in perikaryon	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in synapse	IDA Inferred from Direct Assay more info	PubMed
located_in synapse	IEA Inferred from Electronic Annotation more info
located_in trans-Golgi network transport vesicle	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Protein lin-10

NP_001020996.1

Confirmed by transcript evidence

NP_001129749.1

Confirmed by transcript evidence

NP_492226.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

8109746..8119316 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001025825.5 → NP_001020996.1 Protein lin-10 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001020996.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O17583

Conserved Domains (2) summary

cd00992
Location:862 → 935

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd01208
Location:570 → 739

PTB_X11; X11-like Phosphotyrosine-binding (PTB) domain
NM_059825.8 → NP_492226.2 Protein lin-10 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_492226.2

Status: REVIEWED

UniProtKB/Swiss-Prot

O17583, Q9XZQ5

Conserved Domains (2) summary

cd00992
Location:890 → 963

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd01208
Location:598 → 767

PTB_X11; X11-like Phosphotyrosine-binding (PTB) domain
NM_001136277.4 → NP_001129749.1 Protein lin-10 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001129749.1

Status: REVIEWED

UniProtKB/TrEMBL

B3WFX4

Conserved Domains (2) summary

cd00992
Location:839 → 912

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd01208
Location:547 → 716

PTB_X11; X11-like Phosphotyrosine-binding (PTB) domain