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rlbp-1 Rho-GAP domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 172530, updated on 2-Nov-2024

Summary

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Official Symbol
rlbp-1
Official Full Name
Rho-GAP domain-containing protein
Primary source
WormBase:WBGene00011970
Locus tag
CELE_T23G11.5
See related
AllianceGenome:WB:WBGene00011970
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable GTPase activator activity and small GTPase binding activity. Predicted to be involved in receptor-mediated endocytosis and small GTPase-mediated signal transduction. Human ortholog(s) of this gene implicated in pancreatic adenocarcinoma. Orthologous to human RALBP1 (ralA binding protein 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See rlbp-1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
9
Sequence:
Chromosome: I; NC_003279.8 (7683341..7694210)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Golgin-84 Neighboring gene HAUS6_N domain-containing protein;Vacuolar protein sorting-associated protein VTA1 homolog Neighboring gene eLRR (extracellular Leucine-Rich Repeat) ONly Neighboring gene Hepatocellular carcinoma-associated antigen 59 Neighboring gene Female germline-specific tumor suppressor gld-1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. RAL-1 signaling regulates lipid composition in C. elegans. Wu Y, et al. MicroPubl Biol, 2024. PMID 38454952, Free PMC Article
  2. RAP-1 and the RAL-1/exocyst pathway coordinate hypodermal cell organization in Caenorhabditis elegans. Frische EW, et al. EMBO J, 2007 Dec 12. PMID 17989692, Free PMC Article
  3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
  5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
  
enables small GTPase binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in receptor-mediated endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in small GTPase-mediated signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in small GTPase-mediated signal transduction IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Rho-GAP domain-containing protein
NP_001250565.1
  • Confirmed by transcript evidence
NP_001254005.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    7683341..7694210
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001267076.2 → NP_001254005.1  Rho-GAP domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001254005.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9XVI0
    Conserved Domains (2) summary
    smart00324
    Location:70 → 209
    RhoGAP; GTPase-activator protein for Rho-like GTPases
    PLN02768
    Location:258 → 325
    PLN02768; AMP deaminase

  2. NM_001263636.3 → NP_001250565.1  Rho-GAP domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001250565.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E2JL05
Nucleotide Protein
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Gene LinkOut

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