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rde-2 CABIT domain-containing protein;SH2 domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 172473, updated on 2-Nov-2024

Summary

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Official Symbol
rde-2
Official Full Name
CABIT domain-containing protein;SH2 domain-containing protein
Primary source
WormBase:WBGene00004324
Locus tag
CELE_F21C3.4
See related
AllianceGenome:WB:WBGene00004324
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Involved in meiotic chromosome segregation; regulatory ncRNA-mediated post-transcriptional gene silencing; and siRNA processing. Located in cytosol and mutator focus. Is expressed in germ line. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See rde-2 in Genome Data Viewer
Location:
chromosome: I
Exon count:
9
Sequence:
Chromosome: I; NC_003279.8 (7280466..7282924, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Small integral membrane protein Neighboring gene ncRNA Neighboring gene Histidine triad nucleotide-binding protein 1 Neighboring gene putative prefoldin subunit 6 Neighboring gene DUF4200 domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A heritable antiviral RNAi response limits Orsay virus infection in Caenorhabditis elegans N2. Sterken MG, et al. PLoS One, 2014. PMID 24587016, Free PMC Article
  2. Lack of pairing during meiosis triggers multigenerational transgene silencing in Caenorhabditis elegans. Leopold LE, et al. Proc Natl Acad Sci U S A, 2015 May 19. PMID 25941370, Free PMC Article
  3. RDE-2 interacts with MUT-7 to mediate RNA interference in Caenorhabditis elegans. Tops BB, et al. Nucleic Acids Res, 2005. PMID 15653635, Free PMC Article
  4. Genetic requirements for inheritance of RNAi in C. elegans. Grishok A, et al. Science, 2000 Mar 31. PMID 10741970
  5. RNAi protects the Caenorhabditis elegans germline against transposition. Vastenhouw NL, et al. Trends Genet, 2004 Jul. PMID 15219396

See all (43) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. RNA interference proteins and MUT-7/RDE-2 function together in parallel pathways and/or as multiprotein complexes.
    Title: Caenorhabditis elegans ABCRNAi transporters interact genetically with rde-2 and mut-7.
  2. Interaction between RDE-2 and MUT-7 is required for efficient RNA interference.
    Title: RDE-2 interacts with MUT-7 to mediate RNA interference in Caenorhabditis elegans.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in meiotic chromosome segregation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in post-transcriptional gene silencing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulatory ncRNA-mediated post-transcriptional gene silencing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in siRNA processing IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mutator focus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
CABIT domain-containing protein;SH2 domain-containing protein
NP_001021398.1
  • Confirmed by transcript evidence
NP_001021399.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    7280466..7282924 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001026228.4 → NP_001021399.1  CABIT domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001021399.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q58AA4

  2. NM_001026227.3 → NP_001021398.1  SH2 domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001021398.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q19672
Nucleotide Protein
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