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wago-1 Argonaute protein wago-1 [ Caenorhabditis elegans ]

Gene ID: 172463, updated on 4-Jan-2025

Summary

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Official Symbol
wago-1
Official Full Name
Argonaute protein wago-1
Primary source
WormBase:WBGene00011061
Locus tag
CELE_R06C7.1
See related
AllianceGenome:WB:WBGene00011061
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables DEAD/H-box RNA helicase binding activity. Predicted to be involved in regulatory ncRNA-mediated post-transcriptional gene silencing. Located in P granule. Is expressed in germ line and in male. [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See wago-1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
9
Sequence:
Chromosome: I; NC_003279.8 (7235384..7238792)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene BEN domain-containing protein Neighboring gene ncRNA Neighboring gene Dihydropyrimidinase 1 Neighboring gene Chondroitin proteoglycan 3 Neighboring gene Protein N-terminal glutamine amidohydrolase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. C. elegans germ granules require both assembly and localized regulators for mRNA repression. Aoki ST, et al. Nat Commun, 2021 Feb 12. PMID 33579952, Free PMC Article
  2. A family of C. elegans VASA homologs control Argonaute pathway specificity and promote transgenerational silencing. Dai S, et al. Cell Rep, 2022 Sep 6. PMID 36070689, Free PMC Article
  3. Protease-mediated processing of Argonaute proteins controls small RNA association. Gudipati RK, et al. Mol Cell, 2021 Jun 3. PMID 33852894
  4. ZNFX-1 Functions within Perinuclear Nuage to Balance Epigenetic Signals. Ishidate T, et al. Mol Cell, 2018 May 17. PMID 29775580, Free PMC Article
  5. The Vasa Homolog RDE-12 engages target mRNA and multiple argonaute proteins to promote RNAi in C. elegans. Shirayama M, et al. Curr Biol, 2014 Apr 14. PMID 24684931, Free PMC Article

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Protease-mediated processing of Argonaute proteins controls small RNA association.
    Title: Protease-mediated processing of Argonaute proteins controls small RNA association.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables DEAD/H-box RNA helicase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA endonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables miRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables single-stranded RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in regulatory ncRNA-mediated gene silencing IEA
Inferred from Electronic Annotation
more info
  
involved_in regulatory ncRNA-mediated post-transcriptional gene silencing IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in P granule IDA
Inferred from Direct Assay
more info
 PubMed 
part_of RISC complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasmic ribonucleoprotein granule IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Argonaute protein wago-1
NP_492045.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    7235384..7238792
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_059644.8 → NP_492045.1  Argonaute protein wago-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_492045.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q21770
    Conserved Domains (3) summary
    cd02846
    Location:320 → 430
    PAZ_argonaute_like; PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille. ...
    pfam02171
    Location:598 → 905
    Piwi; Piwi domain
    pfam16486
    Location:70 → 166
    ArgoN; N-terminal domain of argonaute
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q21770.1

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