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plag-15 PhosphoLipase A2 Group [ Caenorhabditis elegans ]

Gene ID: 172457, updated on 4-Jan-2025

Summary

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Official Symbol
plag-15
Official Full Name
PhosphoLipase A2 Group
Primary source
WormBase:WBGene00010872
Locus tag
CELE_M05B5.4
See related
AllianceGenome:WB:WBGene00010872
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable O-acyltransferase activity. Predicted to be involved in lipid metabolic process. Is expressed in several structures, including intestine; muscle cell; neuronal sheath cell; pharynx; and tail. Human ortholog(s) of this gene implicated in Norum disease and arteriosclerosis. Orthologous to several human genes including PLA2G15 (phospholipase A2 group XV). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See plag-15 in Genome Data Viewer
Location:
chromosome: I
Exon count:
6
Sequence:
Chromosome: I; NC_003279.8 (7188465..7190581)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Ion_trans domain-containing protein Neighboring gene Cytoplasmic protein;Flocculation protein FLO11-like;Uncharacterized protein Neighboring gene Helix-loop-helix protein hlh-2 Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. M05B5.4 (lysosomal phospholipase A2) promotes disintegration of autophagic vesicles to maintain C. elegans development. Li Y, et al. Autophagy, 2022 Mar. PMID 34130592, Free PMC Article
  2. Degradation of hexosylceramides is required for timely corpse clearance via formation of cargo-containing phagolysosomal vesicles. Holzapfel R, et al. Eur J Cell Biol, 2024 Jun. PMID 38582051
  3. Cytochrome P450s and short-chain dehydrogenases mediate the toxicogenomic response of PCB52 in the nematode Caenorhabditis elegans. Menzel R, et al. J Mol Biol, 2007 Jun 29. PMID 17499272
  4. Lysosome activity is modulated by multiple longevity pathways and is important for lifespan extension in C. elegans. Sun Y, et al. Elife, 2020 Jun 2. PMID 32482227, Free PMC Article
  5. Comparative genomics and functional study of lipid metabolic genes in Caenorhabditis elegans. Zhang Y, et al. BMC Genomics, 2013 Mar 12. PMID 23496871, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables O-acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in lipid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
PhosphoLipase A2 Group
NP_492033.1
  • Confirmed by transcript evidence;
    Product from WormBase gene class plag

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    7188465..7190581
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_059632.6 → NP_492033.1  PhosphoLipase A2 Group [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_492033.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q21515
    Conserved Domains (1) summary
    pfam02450
    Location:71 → 403
    LCAT; Lecithin:cholesterol acyltransferase
Nucleotide Protein
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