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ubql-1 Ubiquilin [ Caenorhabditis elegans ]

Gene ID: 172434, updated on 4-Jan-2025

Summary

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Official Symbol
ubql-1
Official Full Name
Ubiquilin
Primary source
WormBase:WBGene00008852
Locus tag
CELE_F15C11.2
See related
AllianceGenome:WB:WBGene00008852
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable polyubiquitin modification-dependent protein binding activity. Involved in ERAD pathway; negative regulation of double-strand break repair via homologous recombination; and protein export from nucleus. Predicted to be active in cytosol. Is expressed in hypodermis; intestine; and pharynx. Used to study amyotrophic lateral sclerosis. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis and amyotrophic lateral sclerosis type 15. Orthologous to several human genes including UBQLN1 (ubiquilin 1). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See ubql-1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
12
Sequence:
Chromosome: I; NC_003279.8 (7021972..7029076)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Protein disulfide-isomerase Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Suppression of polyglutamine-induced toxicity in cell and animal models of Huntington's disease by ubiquilin. Wang H, et al. Hum Mol Genet, 2006 Mar 15. PMID 16461334
  2. The polyphenol quercetin protects from glucotoxicity depending on the aggresome in Caenorhabditis elegans. Civelek M, et al. Eur J Nutr, 2020 Mar. PMID 30706126
  3. UBQLN4 Represses Homologous Recombination and Is Overexpressed in Aggressive Tumors. Jachimowicz RD, et al. Cell, 2019 Jan 24. PMID 30612738
  4. Ubiquilin and p97/VCP bind erasin, forming a complex involved in ERAD. Lim PJ, et al. J Cell Biol, 2009 Oct 19. PMID 19822669, Free PMC Article
  5. AKIR-1 regulates proteasome subcellular function in Caenorhabditis elegans. Pispa J, et al. iScience, 2023 Oct 20. PMID 37767001, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables damaged DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables polyubiquitin modification-dependent protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in ERAD pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of double-strand break repair via homologous recombination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nucleotide-excision repair IEA
Inferred from Electronic Annotation
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in protein export from nucleus IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Ubiquilin
NP_740883.1
  • Confirmed by transcript evidence
NP_740884.1
  • Confirmed by transcript evidence
NP_740885.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    7021972..7029076
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_170895.6 → NP_740885.1  Ubiquilin [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_740885.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EG66
    Conserved Domains (2) summary
    cd01808
    Location:8 → 79
    hPLIC_N; Ubiquitin-like domain of hPLIC-1 and hPLIC2
    smart00213
    Location:8 → 79
    UBQ; Ubiquitin homologues

  2. NM_171839.4 → NP_740884.1  Ubiquilin [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_740884.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EC78
    Conserved Domains (3) summary
    cd01808
    Location:8 → 79
    hPLIC_N; Ubiquitin-like domain of hPLIC-1 and hPLIC2
    smart00213
    Location:8 → 79
    UBQ; Ubiquitin homologues
    cd14399
    Location:443 → 482
    UBA_PLICs; UBA domain of eukaryotic protein linking integrin-associated protein (IAP, also known as CD47) with cytoskeleton (PLIC) proteins

  3. NM_170894.5 → NP_740883.1  Ubiquilin [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_740883.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    G5EC78, G5EFF7, G5EG66
    Conserved Domains (3) summary
    cd01808
    Location:8 → 79
    hPLIC_N; Ubiquitin-like domain of hPLIC-1 and hPLIC2
    cd14399
    Location:461 → 500
    UBA_PLICs; UBA domain of eukaryotic protein linking integrin-associated protein (IAP, also known as CD47) with cytoskeleton (PLIC) proteins
    cl28408
    Location:18 → 372
    UBQ; Ubiquitin homologues
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
G5EFF7.1

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