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hrpf-1 RRM domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 172395, updated on 4-Jan-2025

Summary

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Official Symbol
hrpf-1
Official Full Name
RRM domain-containing protein
Primary source
WormBase:WBGene00020936
Locus tag
CELE_W02D3.11
See related
AllianceGenome:WB:WBGene00020936
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable RNA binding activity. Predicted to be involved in regulation of RNA splicing. Predicted to be part of ribonucleoprotein complex. Predicted to be active in nucleoplasm. Is expressed widely. [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See hrpf-1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
7
Sequence:
Chromosome: I; NC_003279.8 (6753219..6756348, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Succinate dehydrogenase assembly factor 4, mitochondrial Neighboring gene Transcription factor unc-37 Neighboring gene FANCI helical domain-containing protein Neighboring gene ncRNA Neighboring gene G protein gamma domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Alternative splicing and the steady-state ratios of mRNA isoforms generated by it are under strong stabilizing selection in Caenorhabditis elegans. Barberan-Soler S, et al. Mol Biol Evol, 2008 Nov. PMID 18718918, Free PMC Article
  2. An autoregulation loop in fust-1 for circular RNA regulation in Caenorhabditis elegans. Cao D. Genetics, 2021 Nov 5. PMID 34740247, Free PMC Article
  3. Genetic modifiers ameliorate endocytic and neuromuscular defects in a model of spinal muscular atrophy. Walsh MB, et al. BMC Biol, 2020 Sep 16. PMID 32938453, Free PMC Article
  4. Alternative splicing regulation during C. elegans development: splicing factors as regulated targets. Barberan-Soler S, et al. PLoS Genet, 2008 Feb 29. PMID 18454200, Free PMC Article
  5. A complex containing the O-GlcNAc transferase OGT-1 and the ubiquitin ligase EEL-1 regulates GABA neuron function. Giles AC, et al. J Biol Chem, 2019 Apr 26. PMID 30858176, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of RNA splicing IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ribonucleoprotein complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
RRM domain-containing protein
NP_001359979.1
  • Confirmed by transcript evidence
NP_740877.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    6753219..6756348 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001372997.1 → NP_001359979.1  RRM domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    H2KZN0
    Conserved Domains (3) summary
    COG0724
    Location:98 → 313
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12254
    Location:7 → 75
    RRM_hnRNPH_ESRPs_RBM12_like; RNA recognition motif found in heterogeneous nuclear ribonucleoprotein (hnRNP) H protein family, epithelial splicing regulatory proteins (ESRPs), Drosophila RNA-binding protein Fusilli, RNA-binding protein 12 (RBM12) and similar proteins
    cd12504
    Location:123 → 199
    RRM2_hnRNPH_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein (hnRNP) H protein family

  2. NM_170888.7 → NP_740877.1  RRM domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_740877.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9BIB7
    Conserved Domains (3) summary
    COG0724
    Location:10 → 183
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12254
    Location:472 → 542
    RRM_hnRNPH_ESRPs_RBM12_like; RNA recognition motif found in heterogeneous nuclear ribonucleoprotein (hnRNP) H protein family, epithelial splicing regulatory proteins (ESRPs), Drosophila RNA-binding protein Fusilli, RNA-binding protein 12 (RBM12) and similar proteins
    cl17169
    Location:123 → 199
    RRM_SF; RNA recognition motif (RRM) superfamily
Nucleotide Protein
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