bag-1 BAG family molecular chaperone regulator 1 [Caenorhabditis elegans] - Gene

Summary

Go to the top of the page Help

Official Symbol: bag-1
Official Full Name: BAG family molecular chaperone regulator 1
Primary source: WormBase:WBGene00000236
Locus tag: CELE_F57B10.11
See related: AllianceGenome:WB:WBGene00000236
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables ATPase activator activity. Predicted to be involved in chaperone cofactor-dependent protein refolding and protein stabilization. Predicted to be active in cytosol; membrane; and nucleus. Human ortholog(s) of this gene implicated in prostate cancer. Orthologous to human BAG1 (BAG cochaperone 1). [provided by Alliance of Genome Resources, Nov 2024]
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

See bag-1 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 3

Sequence:: Chromosome: I; NC_003279.8 (6563629..6564451, complement)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

F57B10.11 (e-PCR)
- UniSTS:320993

F57B10.12 (e-PCR)
- UniSTS:305649

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATPase activator activity	IDA Inferred from Direct Assay more info	PubMed
enables adenyl-nucleotide exchange factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-folding chaperone binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein-folding chaperone binding	IEA Inferred from Electronic Annotation more info
enables protein-folding chaperone binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in chaperone cofactor-dependent protein refolding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in protein stabilization	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

Go to the top of the page Help

Preferred Names: BAG family molecular chaperone regulator 1

NP_491893.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

6563629..6564451 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_059492.8 → NP_491893.1 BAG family molecular chaperone regulator 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_491893.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O44739

Conserved Domains (2) summary

cd01769
Location:23 → 79

UBL; Ubiquitin-like domain of UBL

smart00264
Location:111 → 193

BAG; BAG domains, present in regulator of Hsp70 proteins