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uad-2 Chromo domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 172354, updated on 4-Jan-2025

Summary

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Official Symbol
uad-2
Official Full Name
Chromo domain-containing protein
Primary source
WormBase:WBGene00019429
Locus tag
CELE_K06A5.1
See related
AllianceGenome:WB:WBGene00019429
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables H3K27me3 modified histone binding activity. Involved in positive regulation of piRNA transcription. Located in chromatin and nuclear inner membrane. [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See uad-2 in Genome Data Viewer
Location:
chromosome: I
Exon count:
7
Sequence:
Chromosome: I; NC_003279.8 (6473207..6476756)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Major sperm protein Neighboring gene DUF389 domain membrane protein Neighboring gene M-phase inducer phosphatase cdc-25.1 Neighboring gene CTLH domain-containing protein;WD_REPEATS_REGION domain-containing protein Neighboring gene STAS domain-containing protein Neighboring gene ncRNA Neighboring gene Lariat debranching enzyme Neighboring gene Mediator of RNA polymerase II transcription subunit 18

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A chromodomain protein mediates heterochromatin-directed piRNA expression. Huang X, et al. Proc Natl Acad Sci U S A, 2021 Jul 6. PMID 34187893, Free PMC Article
  2. A transcriptional cofactor regulatory network for the C. elegans intestine. Horowitz BB, et al. G3 (Bethesda), 2023 Jul 5. PMID 37119809, Free PMC Article
  3. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
  4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables H3K27me3 modified histone binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in positive regulation of piRNA transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in chromatin IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear inner membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Chromo domain-containing protein
NP_001300423.1
  • Confirmed by transcript evidence
NP_001300424.1
  • Confirmed by transcript evidence
NP_001379834.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    6473207..6476756
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001313494.3 → NP_001300423.1  Chromo domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3AR81
    Conserved Domains (1) summary
    cd00024
    Location:60 → 105
    CD_CSD; CHROMO (CHRromatin Organization Modifier) domains and chromo shadow domains

  2. NM_001392447.1 → NP_001379834.1  Chromo domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    O44553

  3. NM_001313495.3 → NP_001300424.1  Chromo domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3ATN5
Nucleotide Protein
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