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hrpk-1 Heterogeneous nuclear ribonucleoprotein K homolog [ Caenorhabditis elegans ]

Gene ID: 172330, updated on 2-Nov-2024

Summary

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Official Symbol
hrpk-1
Official Full Name
Heterogeneous nuclear ribonucleoprotein K homolog
Primary source
WormBase:WBGene00017816
Locus tag
CELE_F26B1.2
See related
AllianceGenome:WB:WBGene00017816
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable mRNA binding activity. Involved in DNA damage response and embryo development. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including germ line; hypodermal cell; intestinal cell; muscle cell; and oocyte. Human ortholog(s) of this gene implicated in Raynaud disease. Orthologous to human HNRNPK (heterogeneous nuclear ribonucleoprotein K). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See hrpk-1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
8
Sequence:
Chromosome: I; NC_003279.8 (6317701..6320364)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Serpentine receptor class gamma-14 Neighboring gene Importin subunit alpha-2 Neighboring gene Forkhead box protein F Neighboring gene Uncharacterized protein Neighboring gene MS Related Protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. HRPK-1, a conserved KH-domain protein, modulates microRNA activity during Caenorhabditis elegans development. Li L, et al. PLoS Genet, 2019 Oct. PMID 31584932, Free PMC Article
  2. Systematic, RNA-interference-mediated identification of mus-101 modifier genes in Caenorhabditis elegans. Holway AH, et al. Genetics, 2005 Mar. PMID 15654100, Free PMC Article
  3. Conserved RNA-binding proteins required for dendrite morphogenesis in Caenorhabditis elegans sensory neurons. Antonacci S, et al. G3 (Bethesda), 2015 Feb 10. PMID 25673135, Free PMC Article
  4. Functional proteomics reveals the biochemical niche of C. elegans DCR-1 in multiple small-RNA-mediated pathways. Duchaine TF, et al. Cell, 2006 Jan 27. PMID 16439208
  5. SGPL1 stimulates VPS39 recruitment to the mitochondria in MICU1 deficient cells. Jackson J, et al. Mol Metab, 2022 Jul. PMID 35452878, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA damage response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in embryo development ending in birth or egg hatching IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulatory ncRNA-mediated gene silencing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Heterogeneous nuclear ribonucleoprotein K homolog
NP_001379657.1
  • Confirmed by transcript evidence
NP_001379658.1
  • Confirmed by transcript evidence
NP_001379659.1
  • Confirmed by transcript evidence
NP_001379660.1
  • Confirmed by transcript evidence
NP_740869.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    6317701..6320364
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_170880.6 → NP_740869.1  Heterogeneous nuclear ribonucleoprotein K homolog [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_740869.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P91277, Q8I7G7, Q8I7G8, Q8I7G9, Q8T3B5
    Conserved Domains (3) summary
    cd22432
    Location:49 → 112
    KH-I_HNRNPK_rpt1; first type I K homology (KH) RNA-binding domain found in heterogeneous nuclear ribonucleoprotein K (hnRNP K) and similar proteins
    cd22433
    Location:124 → 193
    KH-I_HNRNPK_rpt2; second type I K homology (KH) RNA-binding domain found in heterogeneous nuclear ribonucleoprotein K (hnRNP K) and similar proteins
    cd22434
    Location:316 → 388
    KH-I_HNRNPK_rpt3; third type I K homology (KH) RNA-binding domain found in heterogeneous nuclear ribonucleoprotein K (hnRNP K) and similar proteins

  2. NM_001392429.1 → NP_001379660.1  Heterogeneous nuclear ribonucleoprotein K homolog [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (1) summary
    cd22432
    Location:49 → 93
    KH-I_HNRNPK_rpt1; first type I K homology (KH) RNA-binding domain found in heterogeneous nuclear ribonucleoprotein K (hnRNP K) and similar proteins

  3. NM_001392432.1 → NP_001379657.1  Heterogeneous nuclear ribonucleoprotein K homolog [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (1) summary
    cl00098
    Location:32 → 61
    KH-I; K homology (KH) RNA-binding domain, type I

  4. NM_001392433.1 → NP_001379659.1  Heterogeneous nuclear ribonucleoprotein K homolog [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (1) summary
    cl00098
    Location:32 → 61
    KH-I; K homology (KH) RNA-binding domain, type I

  5. NM_001392431.1 → NP_001379658.1  Heterogeneous nuclear ribonucleoprotein K homolog [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (3) summary
    cd22432
    Location:32 → 95
    KH-I_HNRNPK_rpt1; first type I K homology (KH) RNA-binding domain found in heterogeneous nuclear ribonucleoprotein K (hnRNP K) and similar proteins
    cd22433
    Location:107 → 176
    KH-I_HNRNPK_rpt2; second type I K homology (KH) RNA-binding domain found in heterogeneous nuclear ribonucleoprotein K (hnRNP K) and similar proteins
    cd22434
    Location:299 → 371
    KH-I_HNRNPK_rpt3; third type I K homology (KH) RNA-binding domain found in heterogeneous nuclear ribonucleoprotein K (hnRNP K) and similar proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P91277.1

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