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pnk-1 Pantothenate kinase [ Caenorhabditis elegans ]

Gene ID: 172327, updated on 4-Jan-2025

Summary

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Official Symbol
pnk-1
Official Full Name
Pantothenate kinase
Primary source
WormBase:WBGene00004068
Locus tag
CELE_C10G11.5
See related
AllianceGenome:WB:WBGene00004068
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable pantothenate kinase activity. Predicted to be involved in coenzyme A biosynthetic process. Predicted to be active in cytosol and nucleus. Human ortholog(s) of this gene implicated in cataract. Orthologous to human PANK4 (pantothenate kinase 4 (inactive)). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See pnk-1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
9
Sequence:
Chromosome: I; NC_003279.8 (6295069..6297636)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Calponin homology domain-containing protein Neighboring gene ncRNA Neighboring gene Verprolin-like Neighboring gene Serpentine Receptor, class H Neighboring gene ncRNA Neighboring gene Serpentine Receptor, class H Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Extracellular 4'-phosphopantetheine is a source for intracellular coenzyme A synthesis. Srinivasan B, et al. Nat Chem Biol, 2015 Oct. PMID 26322826
  2. DAF-16 target genes that control C. elegans life-span and metabolism. Lee SS, et al. Science, 2003 Apr 25. PMID 12690206
  3. Monomethyl branched-chain fatty acids play an essential role in Caenorhabditis elegans development. Kniazeva M, et al. PLoS Biol, 2004 Sep. PMID 15340492, Free PMC Article
  4. RNA targets and specificity of Staufen, a double-stranded RNA-binding protein in Caenorhabditis elegans. LeGendre JB, et al. J Biol Chem, 2013 Jan 25. PMID 23195953, Free PMC Article
  5. C. elegans ORFeome version 1.1: experimental verification of the genome annotation and resource for proteome-scale protein expression. Reboul J, et al. Nat Genet, 2003 May. PMID 12679813

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables pantothenate kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables pantothenate kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in coenzyme A biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in coenzyme A biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Pantothenate kinase
NP_001379655.1
  • Confirmed by transcript evidence
NP_740867.1
  • Confirmed by transcript evidence
NP_740868.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    6295069..6297636
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_170878.5 → NP_740867.1  Pantothenate kinase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_740867.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    H2KYP7
    Conserved Domains (1) summary
    pfam03630
    Location:116 → 439
    Fumble; Fumble

  2. NM_170879.9 → NP_740868.1  Pantothenate kinase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_740868.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    H2KYP8
    Conserved Domains (1) summary
    pfam03630
    Location:116 → 381
    Fumble; Fumble

  3. NM_001392422.1 → NP_001379655.1  Pantothenate kinase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q86NC9
    Conserved Domains (1) summary
    pfam03630
    Location:70 → 393
    Fumble
Nucleotide Protein
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