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fhod-1 FH1/FH2 domain-containing protein 3;FH1/FH2 domain-containing protein 3-like;Formin HOmology Domain [ Caenorhabditis elegans ]

Gene ID: 172133, updated on 9-Dec-2024

Summary

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Official Symbol
fhod-1
Official Full Name
FH1/FH2 domain-containing protein 3;FH1/FH2 domain-containing protein 3-like;Formin HOmology Domain
Primary source
WormBase:WBGene00016735
Locus tag
CELE_C46H11.11
See related
AllianceGenome:WB:WBGene00016735
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable actin filament binding activity. Involved in actin filament organization and embryonic body morphogenesis. Located in actin cytoskeleton. Is expressed in several structures, including intestine; muscle cell; pharynx; reproductive system; and seam cell. Human ortholog(s) of this gene implicated in familial hypertrophic cardiomyopathy. Orthologous to human FHOD1 (formin homology 2 domain containing 1) and FHOD3 (formin homology 2 domain containing 3). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See fhod-1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
19
Sequence:
Chromosome: I; NC_003279.8 (5058251..5068831, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Flavin-containing monooxygenase Neighboring gene F-box C protein;F-box domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene V-type proton ATPase subunit

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. FHOD formin and SRF promote post-embryonic striated muscle growth through separate pathways in C. elegans. Yingling CV, et al. Exp Cell Res, 2021 Jan 1. PMID 33221314, Free PMC Article
  2. INF2- and FHOD-related formins promote ovulation in the somatic gonad of C. elegans. Hegsted A, et al. Cytoskeleton (Hoboken), 2016 Dec. PMID 27770600, Free PMC Article
  3. Loss of Sarcomere-associated Formins Disrupts Z-line Organization, but does not Prevent Thin Filament Assembly in Caenorhabditis elegans Muscle. Mi-Mi L, et al. J Cytol Histol, 2015 Mar. PMID 26161293, Free PMC Article
  4. CYK-1/Formin activation in cortical RhoA signaling centers promotes organismal left-right symmetry breaking. Middelkoop TC, et al. Proc Natl Acad Sci U S A, 2021 May 18. PMID 33972425, Free PMC Article
  5. Tissue-Specific Functions of fem-2/PP2c Phosphatase and fhod-1/formin During Caenorhabditis elegans Embryonic Morphogenesis. Refai O, et al. G3 (Bethesda), 2018 Jul 2. PMID 29720391, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CYK-1/Formin activation in cortical RhoA signaling centers promotes organismal left-right symmetry breaking.
    Title: CYK-1/Formin activation in cortical RhoA signaling centers promotes organismal left-right symmetry breaking.
  2. FHOD formin and SRF promote post-embryonic striated muscle growth through separate pathways in C. elegans.
    Title: FHOD formin and SRF promote post-embryonic striated muscle growth through separate pathways in C. elegans.
  3. EXC-6 plays a role directly in the spermatheca, perhaps by modulating the ability of the spermatheca wall to rapidly accommodate an incoming oocyte, while FHOD-1 may play an indirect role relating to its known importance in the growth and function of the egg-laying muscles
    Title: INF2- and FHOD-related formins promote ovulation in the somatic gonad of C. elegans.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables actin filament binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in actin filament organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cortical actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in embryonic body morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in actin cytoskeleton IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
FH1/FH2 domain-containing protein 3;FH1/FH2 domain-containing protein 3-like;Formin HOmology Domain
NP_001300413.1
  • Confirmed by transcript evidence
NP_001300414.1
  • Confirmed by transcript evidence
NP_001300415.1
  • Confirmed by transcript evidence
NP_001300416.1
  • Product from WormBase gene class fhod;
    Confirmed by transcript evidence
NP_001300417.1
  • Product from WormBase gene class fhod;
    Confirmed by transcript evidence
NP_001300418.1
  • Product from WormBase gene class fhod;
    Confirmed by transcript evidence
NP_001300419.1
  • Product from WormBase gene class fhod;
    Confirmed by transcript evidence
NP_491513.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    5058251..5068831 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001313484.2 → NP_001300413.1  FH1/FH2 domain-containing protein 3 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3AR72
    Conserved Domains (1) summary
    cl19758
    Location:669 → 1029
    FH2; Formin Homology 2 Domain

  2. NM_059112.4 → NP_491513.2  FH1/FH2 domain-containing protein 3-like [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_491513.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EFZ9
    Conserved Domains (1) summary
    cl19758
    Location:827 → 1187
    FH2; Formin Homology 2 Domain

  3. NM_001313486.4 → NP_001300415.1  FH1/FH2 domain-containing protein 3 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3AQN9
    Conserved Domains (1) summary
    cl19758
    Location:686 → 1046
    FH2; Formin Homology 2 Domain

  4. NM_001313485.3 → NP_001300414.1  FH1/FH2 domain-containing protein 3-like [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3ATM4
    Conserved Domains (1) summary
    cl19758
    Location:844 → 1204
    FH2; Formin Homology 2 Domain

  5. NM_001313488.4 → NP_001300417.1  Formin HOmology Domain [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3AWK6
    Conserved Domains (1) summary
    cl19758
    Location:1161 → 1522
    FH2; Formin Homology 2 Domain

  6. NM_001313490.3 → NP_001300419.1  Formin HOmology Domain [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3ATM7
    Conserved Domains (1) summary
    cl19758
    Location:1003 → 1364
    FH2; Formin Homology 2 Domain

  7. NM_001313489.3 → NP_001300418.1  Formin HOmology Domain [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3AR77
    Conserved Domains (1) summary
    cl19758
    Location:1020 → 1381
    FH2; Formin Homology 2 Domain

  8. NM_001313487.3 → NP_001300416.1  Formin HOmology Domain [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3AU72
    Conserved Domains (1) summary
    cl19758
    Location:1178 → 1539
    FH2; Formin Homology 2 Domain
Nucleotide Protein
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