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rnf-145 RING finger protein 145 homolog [ Caenorhabditis elegans ]

Gene ID: 172053, updated on 4-Jan-2025

Summary

Official Symbol
rnf-145
Official Full Name
RING finger protein 145 homolog
Primary source
WormBase:WBGene00022471
Locus tag
CELE_Y119C1B.5
See related
AllianceGenome:WB:WBGene00022471
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in ERAD pathway and proteasome-mediated ubiquitin-dependent protein catabolic process. Located in cis-Golgi network and trans-Golgi network. Is expressed in several structures, including body wall musculature; intestine; nervous system; non-striated muscle; and pharynx. Orthologous to human RNF145 (ring finger protein 145). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

See rnf-145 in Genome Data Viewer
Location:
chromosome: I
Exon count:
12
Sequence:
Chromosome: I; NC_003279.8 (4511438..4516089, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Receptor-type guanylate cyclase gcy-28 Neighboring gene ncRNA Neighboring gene Large ribosomal subunit protein bL19m Neighboring gene Neuropeptide-Like Protein Neighboring gene Conserved plasma membrane protein

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in ERAD pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
located_in cis-Golgi network IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in trans-Golgi network IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
RING finger protein 145 homolog
NP_491382.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    4511438..4516089 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_058981.7NP_491382.2  RING finger protein 145 homolog [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_491382.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q95Y82
    Conserved Domains (2) summary
    cd16476
    Location:590631
    RING-H2_RNF139_like; RING finger, H2 subclass, found in RING finger proteins RNF139, RNF145, and similar proteins
    pfam13705
    Location:49556
    TRC8_N; TRC8 N-terminal domain