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eri-7 Enhanced RNAI (RNA interference) [ Caenorhabditis elegans ]

Gene ID: 172047, updated on 9-Dec-2024

Summary

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Official Symbol
eri-7
Official Full Name
Enhanced RNAI (RNA interference)
Primary source
WormBase:WBGene00016566
Locus tag
CELE_C41D11.7
See related
AllianceGenome:WB:WBGene00016566
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable RNA binding activity and transcription termination site sequence-specific DNA binding activity. Predicted to be involved in termination of RNA polymerase II transcription. Predicted to be active in nuclear body. Is expressed in amphid neurons; gonad; and hypodermis. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis type 4; hypertension; and spinocerebellar ataxia with axonal neuropathy 2. Orthologous to human MOV10 (Mov10 RNA helicase) and SETX (senataxin). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See eri-7 in Genome Data Viewer
Location:
chromosome: I
Exon count:
10
Sequence:
Chromosome: I; NC_003279.8 (4451194..4456805, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene TM2 domain-containing protein C41D11.9 Neighboring gene Protein cmt-1 Neighboring gene Enhanced RNAI (RNA interference) Neighboring gene DNA2/NAM7 helicase helicase domain-containing protein Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Caenorhabditis elegans ADAR editing and the ERI-6/7/MOV10 RNAi pathway silence endogenous viral elements and LTR retrotransposons. Fischer SEJ, et al. Proc Natl Acad Sci U S A, 2020 Mar 17. PMID 32123111, Free PMC Article
  2. A Small-RNA-Mediated Feedback Loop Maintains Proper Levels of 22G-RNAs in C. elegans. Rogers AK, et al. Cell Rep, 2020 Oct 20. PMID 33086057, Free PMC Article
  3. Trans-splicing in C. elegans generates the negative RNAi regulator ERI-6/7. Fischer SE, et al. Nature, 2008 Sep 25. PMID 18784652, Free PMC Article
  4. Multiple small RNA pathways regulate the silencing of repeated and foreign genes in C. elegans. Fischer SE, et al. Genes Dev, 2013 Dec 15. PMID 24352423, Free PMC Article
  5. Diversification of small RNA pathways underlies germline RNA interference incompetence in wild Caenorhabditis elegans strains. Chou HT, et al. Genetics, 2024 Jan 3. PMID 37865119, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A Small-RNA-Mediated Feedback Loop Maintains Proper Levels of 22G-RNAs in C. elegans.
    Title: A Small-RNA-Mediated Feedback Loop Maintains Proper Levels of 22G-RNAs in C. elegans.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables transcription termination site sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in termination of RNA polymerase II transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nuclear body IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Enhanced RNAI (RNA interference)
NP_491374.2
  • Product from WormBase gene class eri;
    Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    4451194..4456805 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_058973.8 → NP_491374.2  Enhanced RNAI (RNA interference) [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_491374.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    O01976
    Conserved Domains (3) summary
    pfam13086
    Location:67 → 273
    AAA_11; AAA domain
    pfam13087
    Location:284 → 502
    AAA_12; AAA domain
    pfam13245
    Location:77 → 131
    AAA_19; Part of AAA domain
Nucleotide Protein
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