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hop-1 Presenilin hop-1 [ Caenorhabditis elegans ]

Gene ID: 172017, updated on 9-Dec-2024

Summary

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Official Symbol
hop-1
Official Full Name
Presenilin hop-1
Primary source
WormBase:WBGene00001985
Locus tag
CELE_C18E3.8
See related
AllianceGenome:WB:WBGene00001985
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable endopeptidase activity. Involved in several processes, including egg-laying behavior; positive regulation of Notch signaling pathway; and regulation of vulval development. Predicted to be located in Golgi membrane and endoplasmic reticulum membrane. Predicted to be part of gamma-secretase complex. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See hop-1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
6
Sequence:
Chromosome: I; NC_003279.8 (4208515..4210341, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene C-CAP/cofactor C-like domain-containing protein Neighboring gene WD_REPEATS_REGION domain-containing protein Neighboring gene ULP_PROTEASE domain-containing protein Neighboring gene SWI/SNF chromatin-remodeling accessory subunit 2 Neighboring gene ncRNA Neighboring gene MSP domain-containing protein Neighboring gene C3H1-type domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. CoREST-like complexes regulate chromatin modification and neuronal gene expression. Lakowski B, et al. J Mol Neurosci, 2006. PMID 17085781
  2. Reverse genetic analysis of Caenorhabditis elegans presenilins reveals redundant but unequal roles for sel-12 and hop-1 in Notch-pathway signaling. Westlund B, et al. Proc Natl Acad Sci U S A, 1999 Mar 2. PMID 10051671, Free PMC Article
  3. The presenilin protein family member SPE-4 localizes to an ER/Golgi derived organelle and is required for proper cytoplasmic partitioning during Caenorhabditis elegans spermatogenesis. Arduengo PM, et al. J Cell Sci, 1998 Dec 18. PMID 9819355
  4. Mutation of hop-1 and pink-1 attenuates vulnerability of neurotoxicity in C. elegans: the role of mitochondria-associated membrane proteins in Parkinsonism. Wu S, et al. Exp Neurol, 2018 Nov. PMID 30076829, Free PMC Article
  5. HOP-1 Presenilin Deficiency Causes a Late-Onset Notch Signaling Phenotype That Affects Adult Germline Function in Caenorhabditis elegans. Agarwal I, et al. Genetics, 2018 Feb. PMID 29242286, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The findings of this study suggest that presenilin and PINK1 play important roles in the RO/PQ-induced neurotoxicity through the mechanisms involved in mitochondria-associated membranes.
    Title: Mutation of hop-1 and pink-1 attenuates vulnerability of neurotoxicity in C. elegans: the role of mitochondria-associated membrane proteins in Parkinsonism.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables aspartic endopeptidase activity, intramembrane cleaving IEA
Inferred from Electronic Annotation
more info
  
enables endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in Notch signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in Notch signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in amyloid-beta formation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in calcium ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in egg-laying behavior IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in embryo development ending in birth or egg hatching IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in gonad development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in membrane protein ectodomain proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nematode larval development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of Notch signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of cell population proliferation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in protein processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein processing IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cell fate specification IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of vulval development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in reproductive process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in reproductive process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
part_of gamma-secretase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Presenilin hop-1
NP_491328.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    4208515..4210341 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_058927.2 → NP_491328.1  Presenilin hop-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_491328.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O02100
    Conserved Domains (1) summary
    cl01342
    Location:8 → 348
    Peptidase_A22B; Signal peptide peptidase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O02100.1

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