E01A2.1 GCS light chain [Caenorhabditis elegans] - Gene

Summary

Go to the top of the page Help

Official Symbol: E01A2.1
Official Full Name: GCS light chain
Primary source: WormBase:WBGene00017084
Locus tag: CELE_E01A2.1
See related: AllianceGenome:WB:WBGene00017084
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable glutamate-cysteine ligase catalytic subunit binding activity and glutamate-cysteine ligase regulator activity. Predicted to be involved in glutathione biosynthetic process. Predicted to be part of glutamate-cysteine ligase complex. Human ortholog(s) of this gene implicated in myocardial infarction and vascular dementia. Orthologous to human GCLM (glutamate-cysteine ligase modifier subunit). [provided by Alliance of Genome Resources, Dec 2024]
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

See E01A2.1 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 6

Sequence:: Chromosome: I; NC_003279.8 (4139558..4142367)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

E01A2.i (e-PCR)
- UniSTS:323548

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables glutamate-cysteine ligase catalytic subunit binding	IBA Inferred from Biological aspect of Ancestor more info
enables glutamate-cysteine ligase catalytic subunit binding	IEA Inferred from Electronic Annotation more info
enables glutamate-cysteine ligase regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in glutathione biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glutathione biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of glutamate-cysteine ligase complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

Go to the top of the page Help

Preferred Names: GCS light chain

NP_001367719.1

Confirmed by transcript evidence

NP_001379848.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

4139558..4142367

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001379700.1 → NP_001367719.1 GCS light chain [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A9CZN9

Conserved Domains (1) summary

cl00470
Location:92 → 224

AKR_SF; Aldo-keto reductase (AKR) superfamily
NM_001392097.1 → NP_001379848.1 GCS light chain [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

Q966L2

Conserved Domains (1) summary

cl00470
Location:78 → 210

AKR_SF; Aldo-keto reductase (AKR) superfamily