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fog-1 RRM domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 171895, updated on 4-Jan-2025

Summary

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Official Symbol
fog-1
Official Full Name
RRM domain-containing protein
Primary source
WormBase:WBGene00001481
Locus tag
CELE_Y54E10A.4
See related
AllianceGenome:WB:WBGene00001481
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables mRNA 3'-UTR binding activity. Involved in cell fate specification; germ-line sex determination; and spermatogenesis. Located in cytoplasm and nuclear periphery. Is expressed in germ line. [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See fog-1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
9
Sequence:
Chromosome: I; NC_003279.8 (3211046..3217267)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene DOMON domain-containing protein Neighboring gene rhomboid protease Neighboring gene CDT1 Geminin-binding domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. In Caenorhabditis elegans, the RNA-binding domains of the cytoplasmic polyadenylation element binding protein FOG-1 are needed to regulate germ cell fates. Jin SW, et al. Genetics, 2001 Dec. PMID 11779801, Free PMC Article
  2. Genomic Analyses of Sperm Fate Regulator Targets Reveal a Common Set of Oogenic mRNAs in Caenorhabditis elegans. Noble DC, et al. Genetics, 2016 Jan. PMID 26564160, Free PMC Article
  3. Regulation of cell fate in Caenorhabditis elegans by a novel cytoplasmic polyadenylation element binding protein. Jin SW, et al. Dev Biol, 2001 Jan 15. PMID 11150246
  4. Functional divergence of orthologous temperature-sensitive mutations in C. elegans and C. briggsae. Velayudhan SS, et al. MicroPubl Biol, 2022. PMID 36575738, Free PMC Article
  5. Sex Determination in Nematode Germ Cells. Ellis RE. Sex Dev, 2022. PMID 35172320, Free PMC Article

See all (78) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. FOG-1 and FOG-3 work in a complex to repress oogenic transcripts and thereby promote the sperm fate
    Title: Genomic Analyses of Sperm Fate Regulator Targets Reveal a Common Set of Oogenic mRNAs in Caenorhabditis elegans.
  2. FOG-1 protein is barely detectable in proliferating germ cells, but abundant in germ cells destined for spermatogenesis
    Title: Dose-dependent control of proliferation and sperm specification by FOG-1/CPEB.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA 3'-UTR binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mRNA 3'-UTR binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables mRNA 3'-UTR binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA regulatory element binding translation repressor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables ribosome binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables translation factor activity, RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables translation regulator activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell fate specification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in germ-line sex determination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of cytoplasmic translation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of translation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of translation TAS
Traceable Author Statement
more info
 PubMed 
involved_in spermatogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear periphery IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
RRM domain-containing protein
NP_001300469.1
  • Confirmed by transcript evidence
NP_001300470.1
  • Confirmed by transcript evidence
NP_001367956.1
  • Confirmed by transcript evidence
NP_001367957.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    3211046..3217267
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001381586.3 → NP_001367956.1  RRM domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95XX9
    Conserved Domains (2) summary
    cd19757
    Location:353 → 384
    Bbox1; B-box-type 1 zinc finger (Bbox1)
    cl17169
    Location:105 → 185
    RRM_SF; RNA recognition motif (RRM) superfamily

  2. NM_001381585.1 → NP_001367957.1  RRM domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EBS6
    Conserved Domains (1) summary
    cl17169
    Location:319 → 399
    RRM_SF; RNA recognition motif (RRM) superfamily

  3. NM_001313540.3 → NP_001300469.1  RRM domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3ATT1
    Conserved Domains (2) summary
    cd19757
    Location:298 → 329
    Bbox1; B-box-type 1 zinc finger (Bbox1)
    cl17169
    Location:50 → 130
    RRM_SF; RNA recognition motif (RRM) superfamily

  4. NM_001313541.3 → NP_001300470.1  RRM domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3AQU4
    Conserved Domains (1) summary
    pfam16366
    Location:25 → 45
    CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
Nucleotide Protein
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