U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

mod-5 Transporter [ Caenorhabditis elegans ]

Gene ID: 171879, updated on 4-Jan-2025

Summary

Go to the top of the page Help
Official Symbol
mod-5
Official Full Name
Transporter
Primary source
WormBase:WBGene00003387
Locus tag
CELE_Y54E10BR.7
See related
AllianceGenome:WB:WBGene00003387
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables serotonin:sodium:chloride symporter activity. Involved in serotonin uptake. Predicted to be located in membrane and presynapse. Predicted to be active in neuron projection; plasma membrane; and synapse. Is expressed in several structures, including nerve ring. Used to study cocaine abuse. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; anxiety disorder (multiple); depressive disorder (multiple); heart disease (multiple); and substance abuse (multiple). Orthologous to human SLC6A4 (solute carrier family 6 member 4). [provided by Alliance of Genome Resources, Jan 2025]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See mod-5 in Genome Data Viewer
Location:
chromosome: I
Exon count:
12
Sequence:
Chromosome: I; NC_003279.8 (3034716..3047794, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene RING-type E3 ubiquitin transferase Neighboring gene Signal peptidase complex catalytic subunit SEC11 Neighboring gene ADP-ribosylation factor-related protein 1 Neighboring gene DNA-directed RNA polymerase II subunit RPB7 Neighboring gene C2H2-type domain-containing protein Neighboring gene GPI ethanolamine phosphate transferase 1 Neighboring gene Actin-related protein 2/3 complex subunit 5

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Mutations in the Caenorhabditis elegans serotonin reuptake transporter MOD-5 reveal serotonin-dependent and -independent activities of fluoxetine. Ranganathan R, et al. J Neurosci, 2001 Aug 15. PMID 11487610, Free PMC Article
  2. Basal pharyngeal pumping elevated in C. elegans mod-5 mutants. Hiebert T, et al. MicroPubl Biol, 2017 Feb 8. PMID 32550351, Free PMC Article
  3. Precision deletion of the entire coding sequence of the mod-5 locus causes increase in pharyngeal pumping frequency. Brock T, et al. MicroPubl Biol, 2017 Jun 6. PMID 32550363, Free PMC Article
  4. Natural variation in the Caenorhabditis elegans egg-laying circuit modulates an intergenerational fitness trade-off. Mignerot L, et al. Elife, 2024 Apr 2. PMID 38564369, Free PMC Article
  5. The serotonin circuit that coordinates germline proliferation and egg laying with other reproductive functions in Caenorhabditis elegans. Aprison EZ, et al. Proc Biol Sci, 2022 Nov 30. PMID 36448283, Free PMC Article

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables serotonin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables serotonin:sodium:chloride symporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables serotonin:sodium:chloride symporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables symporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in amino acid transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in serotonin uptake IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in serotonin uptake IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sodium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IC
Inferred by Curator
more info
 PubMed 
located_in presynapse IEA
Inferred from Electronic Annotation
more info
  
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
Transporter
NP_491095.3
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    3034716..3047794 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_058694.4 → NP_491095.3  Transporter [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_491095.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q963F3, Q9N3C7
    Conserved Domains (1) summary
    cd11497
    Location:100 → 639
    SLC6sbd_SERT-like; Na(+)- and Cl(-)-dependent monoamine transporters, SERT, NET, DAT1 and related proteins; solute binding domain
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools
Miscellaneous