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lin-65 ML domain-containing protein;RING-type domain-containing protein;Uncharacterized protein [ Caenorhabditis elegans ]

Gene ID: 171739, updated on 4-Jan-2025

Summary

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Official Symbol
lin-65
Official Full Name
ML domain-containing protein;RING-type domain-containing protein;Uncharacterized protein
Primary source
WormBase:WBGene00022149
Locus tag
CELE_Y71G12B.9
See related
AllianceGenome:WB:WBGene00022149
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Involved in chromatin remodeling and mitochondrial unfolded protein response. Located in cytosol and nucleus. Is expressed in head neurons and intestine. [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See lin-65 in Genome Data Viewer
Location:
chromosome: I
Exon count:
8
Sequence:
Chromosome: I; NC_003279.8 (1755329..1766400)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene FERM domain-containing protein;I/LWEQ domain-containing protein;Talin central domain-containing protein Neighboring gene Mitochondrial-processing peptidase subunit alpha Neighboring gene hydroxymethylglutaryl-CoA lyase Neighboring gene MFS domain-containing protein;Major facilitator superfamily (MFS) profile domain-containing protein Neighboring gene RNA helicase Neighboring gene MFS domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Simplified detection of a point mutation in C. elegans using tetra-primer ARMS-PCR. Sullenberger M, et al. MicroPubl Biol, 2018 Dec 9. PMID 32550372, Free PMC Article
  2. Regulated nuclear accumulation of a histone methyltransferase times the onset of heterochromatin formation in C. elegans embryos. Mutlu B, et al. Sci Adv, 2018 Aug. PMID 30140741, Free PMC Article
  3. Heterochromatic foci and transcriptional repression by an unstructured MET-2/SETDB1 co-factor LIN-65. Delaney CE, et al. J Cell Biol, 2019 Mar 4. PMID 30737265, Free PMC Article
  4. Mitochondrial Stress Induces Chromatin Reorganization to Promote Longevity and UPR(mt). Tian Y, et al. Cell, 2016 May 19. PMID 27133166, Free PMC Article
  5. Caenorhabditis elegans homologue of Fam210 is required for oogenesis and reproduction. Kang J, et al. J Genet Genomics, 2020 Nov 20. PMID 33547005

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in chromatin remodeling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitochondrial unfolded protein response IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in mitochondrial unfolded protein response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
ML domain-containing protein;RING-type domain-containing protein;Uncharacterized protein
NP_001293438.1
  • Confirmed by transcript evidence
NP_740785.2
  • Confirmed by transcript evidence
NP_740786.3
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    1755329..1766400
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_170802.6 → NP_740785.2  Uncharacterized protein CELE_Y71G12B.9 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_740785.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q4VNJ8, Q4VNJ9, Q95XN0

  2. NM_170803.6 → NP_740786.3  RING-type domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_740786.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IU04

  3. NM_001306509.3 → NP_001293438.1  ML domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293438.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    W6RTP0
Nucleotide Protein
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