Y92H12A.2 E3 ubiquitin-protein ligase;HECT-type E3 ubiquitin transferase [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: Y92H12A.2
Official Full Name: E3 ubiquitin-protein ligase;HECT-type E3 ubiquitin transferase
Primary source: WormBase:WBGene00022358
Locus tag: CELE_Y92H12A.2
See related: AllianceGenome:WB:WBGene00022358
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable sodium channel inhibitor activity and ubiquitin protein ligase activity. Predicted to be involved in regulation of dendrite morphogenesis and ubiquitin-dependent protein catabolic process. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in periventricular nodular heterotopia. Orthologous to human NEDD4 (NEDD4 E3 ubiquitin protein ligase) and NEDD4L (NEDD4 like E3 ubiquitin protein ligase). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See Y92H12A.2 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 11

Sequence:: Chromosome: I; NC_003279.8 (1543525..1556196)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables sodium channel inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin-protein transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in regulation of dendrite morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: E3 ubiquitin-protein ligase;HECT-type E3 ubiquitin transferase

NP_001293292.1

Confirmed by transcript evidence

NP_490865.4

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

1543525..1556196

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001306363.2 → NP_001293292.1 E3 ubiquitin-protein ligase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001293292.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A061ACQ8

Conserved Domains (5) summary

smart00456
Location:323 → 353

WW; Domain with 2 conserved Trp (W) residues

smart00119
Location:415 → 720

HECTc; Domain Homologous to E6-AP Carboxyl Terminus with

cd00078
Location:393 → 721

HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

pfam00397
Location:272 → 301

WW; WW domain

cl14603
Location:20 → 147

C2; C2 domain
NM_058464.9 → NP_490865.4 HECT-type E3 ubiquitin transferase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_490865.4

Status: REVIEWED

UniProtKB/TrEMBL

Q9BKW4

Conserved Domains (4) summary

smart00456
Location:72 → 102

WW; Domain with 2 conserved Trp (W) residues

smart00119
Location:164 → 492

HECTc; Domain Homologous to E6-AP Carboxyl Terminus with

cd00078
Location:142 → 493

HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

pfam00397
Location:21 → 50

WW; WW domain