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spe-15 Myosin VI cargo binding domain-containing protein;Myosin motor domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 171712, updated on 4-Jan-2025

Summary

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Official Symbol
spe-15
Official Full Name
Myosin VI cargo binding domain-containing protein;Myosin motor domain-containing protein
Primary source
WormBase:WBGene00004969
Locus tag
CELE_F47G6.4
See related
AllianceGenome:WB:WBGene00004969
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable actin filament binding activity and microfilament motor activity. Involved in organelle localization and spermatid development. Predicted to be located in myofibril. Predicted to be part of myosin complex. Predicted to be active in actin cytoskeleton; endocytic vesicle; and plasma membrane. Is expressed in primary spermatocyte. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 22; autosomal recessive nonsyndromic deafness 37; ovarian cancer; and sensorineural hearing loss. Orthologous to human MYO6 (myosin VI). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See spe-15 in Genome Data Viewer
Location:
chromosome: I
Exon count:
18
Sequence:
Chromosome: I; NC_003279.8 (1446497..1465358)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene putative signal recognition particle 19 kDa protein Neighboring gene ncRNA Neighboring gene tRNA-Arg Neighboring gene ncRNA Neighboring gene Glutathione S-transferase Neighboring gene LEM domain-containing protein Neighboring gene AMP-dependent synthetase/ligase domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Myosin VI is required for asymmetric segregation of cellular components during C. elegans spermatogenesis. Kelleher JF, et al. Curr Biol, 2000 Nov 30. PMID 11114515
  2. Effects of Microcystin-LR Exposure on Spermiogenesis in Nematode Caenorhabditis elegans. Li Y, et al. Int J Mol Sci, 2015 Sep 22. PMID 26402677, Free PMC Article
  3. Distinct roles of two myosins in C. elegans spermatid differentiation. Hu J, et al. PLoS Biol, 2019 Apr. PMID 30990821, Free PMC Article
  4. A family of unconventional myosins from the nematode Caenorhabditis elegans. Baker JP, et al. J Mol Biol, 1997 Oct 3. PMID 9325109
  5. Unconventional Myosins from Caenorhabditis elegans as a Probe to Study Human Orthologues. Johnson CA, et al. Biomolecules, 2022 Dec 16. PMID 36551317, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables actin filament binding IEA
Inferred from Electronic Annotation
more info
  
enables cytoskeletal motor activity IEA
Inferred from Electronic Annotation
more info
  
enables microfilament motor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in actin filament-based movement IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in organelle localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in spermatid development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in spermatogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in endocytic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in intracellular membraneless organelle IEA
Inferred from Electronic Annotation
more info
  
located_in myofibril IEA
Inferred from Electronic Annotation
more info
  
part_of myosin complex IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Myosin VI cargo binding domain-containing protein;Myosin motor domain-containing protein
NP_001293430.1
  • Confirmed by transcript evidence
NP_001293431.1
  • Confirmed by transcript evidence
NP_490856.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    1446497..1465358
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_058455.6 → NP_490856.1  Myosin motor domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_490856.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9TZI9
    Conserved Domains (5) summary
    smart00015
    Location:820 → 837
    IQ; Calmodulin-binding motif
    cd01382
    Location:78 → 761
    MYSc_Myo6; class VI myosin, motor domain
    pfam02736
    Location:12 → 49
    Myosin_N; Myosin N-terminal SH3-like domain
    pfam05672
    Location:929 → 1000
    MAP7; MAP7 (E-MAP-115) family
    pfam16521
    Location:1123 → 1211
    Myosin-VI_CBD; Myosin VI cargo binding domain

  2. NM_001306501.3 → NP_001293430.1  Myosin motor domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293430.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    W6RY57
    Conserved Domains (3) summary
    COG5022
    Location:2 → 328
    COG5022; Myosin heavy chain [General function prediction only]
    cl22853
    Location:1 → 84
    Motor_domain; Myosin and Kinesin motor domain
    pfam16521
    Location:446 → 534
    Myosin-VI_CBD; Myosin VI cargo binding domain

  3. NM_001306502.3 → NP_001293431.1  Myosin VI cargo binding domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293431.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    W6RRZ0
    Conserved Domains (2) summary
    pfam07946
    Location:104 → 151
    DUF1682; Protein of unknown function (DUF1682)
    pfam16521
    Location:268 → 356
    Myosin-VI_CBD; Myosin VI cargo binding domain
Nucleotide Protein
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