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haf-6 ABC transporter ATP-binding protein;ATP-binding cassette sub-family B member 8, mitochondrial [ Caenorhabditis elegans ]

Gene ID: 171694, updated on 2-Nov-2024

Summary

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Official Symbol
haf-6
Official Full Name
ABC transporter ATP-binding protein;ATP-binding cassette sub-family B member 8, mitochondrial
Primary source
WormBase:WBGene00001816
Locus tag
CELE_Y48G8AL.11
See related
AllianceGenome:WB:WBGene00001816
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable ATPase-coupled transmembrane transporter activity. Involved in regulatory ncRNA-mediated post-transcriptional gene silencing. Located in perinuclear endoplasmic reticulum. Is expressed in germ line; intestine; and muscle cell. Orthologous to human ABCB8 (ATP binding cassette subfamily B member 8). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See haf-6 in Genome Data Viewer
Location:
chromosome: I
Exon count:
10
Sequence:
Chromosome: I; NC_003279.8 (1162880..1175809, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Origin recognition complex subunit 6 Neighboring gene Large ribosomal subunit protein uL22 Neighboring gene Regulator of nonsense transcripts 1 Neighboring gene ncRNA Neighboring gene Doublecortin domain-containing protein;SAM-dependent MTase RsmB/NOP-type domain-containing protein;tRNA (cytosine(34)-C(5))-methyltransferase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. ABC transporters and RNAi in Caenorhabditis elegans. Timmons LD. J Bioenerg Biomembr, 2007 Dec. PMID 17994271
  2. The Caenorhabditis elegans rsd-2 and rsd-6 genes are required for chromosome functions during exposure to unfavorable environments. Han W, et al. Genetics, 2008 Apr. PMID 18430922, Free PMC Article
  3. Nucleotide excision repair genes are expressed at low levels and are not detectably inducible in Caenorhabditis elegans somatic tissues, but their function is required for normal adult life after UVC exposure. Boyd WA, et al. Mutat Res, 2010 Jan 5. PMID 19879883, Free PMC Article
  4. ATP-binding cassette transporters are required for efficient RNA interference in Caenorhabditis elegans. Sundaram P, et al. Mol Biol Cell, 2006 Aug. PMID 16723499, Free PMC Article
  5. Caenorhabditis elegans ABCRNAi transporters interact genetically with rde-2 and mut-7. Sundaram P, et al. Genetics, 2008 Feb. PMID 18245353, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ABC-type transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATPase-coupled transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in regulatory ncRNA-mediated post-transcriptional gene silencing IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulatory ncRNA-mediated post-transcriptional gene silencing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to chemical IEA
Inferred from Electronic Annotation
more info
  
involved_in siderophore transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in siderophore-dependent iron import into cell IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in perinuclear endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
ABC transporter ATP-binding protein;ATP-binding cassette sub-family B member 8, mitochondrial
NP_001293230.1
  • Confirmed by transcript evidence
NP_001293231.1
  • Confirmed by transcript evidence
NP_490828.3
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    1162880..1175809 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_058427.7 → NP_490828.3  ATP-binding cassette sub-family B member 8, mitochondrial [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_490828.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9BL17
    Conserved Domains (3) summary
    cd03249
    Location:425 → 663
    ABC_MTABC3_MDL1_MDL2; ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins
    COG1132
    Location:87 → 663
    MdlB; ABC-type multidrug transport system, ATPase and permease component [Defense mechanisms]
    pfam00664
    Location:102 → 378
    ABC_membrane; ABC transporter transmembrane region

  2. NM_001306301.3 → NP_001293230.1  ATP-binding cassette sub-family B member 8, mitochondrial [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293230.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    V6CKC7
    Conserved Domains (1) summary
    COG1132
    Location:3 → 512
    MdlB; ABC-type multidrug transport system, ATPase and permease component [Defense mechanisms]

  3. NM_001306302.3 → NP_001293231.1  ABC transporter ATP-binding protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293231.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    V6CLQ7
    Conserved Domains (1) summary
    cl38936
    Location:2 → 62
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
Nucleotide Protein
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