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acs-13 Long-chain-fatty-acid--CoA ligase [ Caenorhabditis elegans ]

Gene ID: 171643, updated on 9-Dec-2024

Summary

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Official Symbol
acs-13
Official Full Name
Long-chain-fatty-acid--CoA ligase
Primary source
WormBase:WBGene00022037
Locus tag
CELE_Y65B4BL.5
See related
AllianceGenome:WB:WBGene00022037
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable long-chain fatty acid-CoA ligase activity. Predicted to be involved in long-chain fatty acid metabolic process. Predicted to be active in endoplasmic reticulum and membrane. Is expressed in body wall musculature; head; hypodermis; intestine; and pharynx. Human ortholog(s) of this gene implicated in acute myeloid leukemia; congenital diarrhea; and leukemia. Orthologous to human ACSL1 (acyl-CoA synthetase long chain family member 1); ACSL5 (acyl-CoA synthetase long chain family member 5); and ACSL6 (acyl-CoA synthetase long chain family member 6). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See acs-13 in Genome Data Viewer
Location:
chromosome: I
Exon count:
7
Sequence:
Chromosome: I; NC_003279.8 (511044..519646, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Dolichyl-phosphate-mannose--protein mannosyltransferase Neighboring gene P-granule-associated protein deps-1 Neighboring gene Transmembrane protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene (Na+)-NQR maturation NqrM Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A genetic titration of membrane composition in Caenorhabditis elegans reveals its importance for multiple cellular and physiological traits. Devkota R, et al. Genetics, 2021 Aug 26. PMID 34125894, Free PMC Article
  2. Evolutionarily conserved long-chain Acyl-CoA synthetases regulate membrane composition and fluidity. Ruiz M, et al. Elife, 2019 Nov 26. PMID 31769755, Free PMC Article
  3. Paradigm shift: the primary function of the "Adiponectin Receptors" is to regulate cell membrane composition. Pilon M. Lipids Health Dis, 2021 Apr 30. PMID 33931104, Free PMC Article
  4. Identification of CED-3 substrates by a yeast-based screening method. Kim SY, et al. Mol Biotechnol, 2004 May. PMID 15122042
  5. Dietary S. maltophilia induces supersized lipid droplets by enhancing lipogenesis and ER-LD contacts in C. elegans. Xie K, et al. Gut Microbes, 2022 Jan-Dec. PMID 35112996, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables long-chain fatty acid-CoA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Long-chain-fatty-acid--CoA ligase
NP_001293196.1
  • Confirmed by transcript evidence
NP_001368382.1
  • Confirmed by transcript evidence
NP_490744.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    511044..519646 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_058343.5 → NP_490744.1  Long-chain-fatty-acid--CoA ligase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_490744.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9N302
    Conserved Domains (1) summary
    cd05927
    Location:140 → 716
    LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)

  2. NM_001306267.3 → NP_001293196.1  Long-chain-fatty-acid--CoA ligase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293196.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    V6CLI5
    Conserved Domains (1) summary
    cd05927
    Location:147 → 723
    LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)

  3. NM_001379780.1 → NP_001368382.1  Long-chain-fatty-acid--CoA ligase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    V6CK48
    Conserved Domains (1) summary
    cd05927
    Location:97 → 673
    LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
Nucleotide Protein
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