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homt-1 Alpha N-terminal protein methyltransferase 1 [ Caenorhabditis elegans ]

Gene ID: 171590, updated on 2-Nov-2024

Summary

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Official Symbol
homt-1
Official Full Name
Alpha N-terminal protein methyltransferase 1
Primary source
WormBase:WBGene00022277
Locus tag
CELE_Y74C9A.3
See related
AllianceGenome:WB:WBGene00022277
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable N-terminal protein N-methyltransferase activity. Predicted to be involved in N-terminal protein amino acid methylation. Predicted to be active in cytoplasm. Is expressed in PVT and uterus. Orthologous to several human genes including NTMT1 (N-terminal Xaa-Pro-Lys N-methyltransferase 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See homt-1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
5
Sequence:
Chromosome: I; NC_003279.8 (4116..10230, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Peptide P4 Neighboring gene REST corepressor rcor-1 Neighboring gene pseudo

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Melatonin signaling regulates locomotion behavior and homeostatic states through distinct receptor pathways in Caenorhabditis elegans. Tanaka D, et al. Neuropharmacology, 2007 Jul. PMID 17573073
  2. Amino acid and protein specificity of protein fatty acylation in C. elegans. Zhang B, et al. Proc Natl Acad Sci U S A, 2024 Jan 30. PMID 38252833, Free PMC Article
  3. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
  4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables N-terminal protein N-methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables N-terminal protein N-methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in N-terminal protein amino acid methylation IEA
Inferred from Electronic Annotation
more info
  
involved_in methylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Alpha N-terminal protein methyltransferase 1
NP_490660.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    4116..10230 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_058260.8 → NP_490660.1  Alpha N-terminal protein methyltransferase 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_490660.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9N4D9
    Conserved Domains (1) summary
    pfam05891
    Location:11 → 225
    Methyltransf_PK; AdoMet dependent proline di-methyltransferase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9N4D9.2

Gene LinkOut

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