Crispld2 cysteine-rich secretory protein LCCL domain containing 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Crispld2provided by RGD
Official Full Name: cysteine-rich secretory protein LCCL domain containing 2provided by RGD
Primary source: RGD:620860
See related: EnsemblRapid:ENSRNOG00000016752 AllianceGenome:RGD:620860
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Lgl1; Lcrisp2
Summary: Predicted to enable heparin binding activity. Involved in lung development. Predicted to be located in extracellular matrix and transport vesicle. Predicted to be active in extracellular space. Orthologous to human CRISPLD2 (cysteine rich secretory protein LCCL domain containing 2). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Biased expression in Heart (RPKM 132.9), Uterus (RPKM 130.1) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 19q12

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	19	NC_086037.1 (64961764..65020099)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	19	NC_051354.1 (48053153..48111485)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	19	NC_005118.4 (52647038..52705118)

Chromosome 19 - NC_086037.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Scribble/Lgl/Dlg polarity protein complex is a regulator of blood-testis barrier dynamics and spermatid polarity during spermatogenesis
Title: The Scribble/Lgl/Dlg polarity protein complex is a regulator of blood-testis barrier dynamics and spermatid polarity during spermatogenesis.
the Lgl1 regulation of Rab10 stimulates the trafficking of membrane precursor vesicles, whose fusion with the plasmalemma is crucial for axonal growth.
Title: Lgl1 activation of rab10 promotes axonal membrane trafficking underlying neuronal polarization.
Upregulation of LGL1 pulmonary gene expression after RA treatment may promote lung growth by stimulating alveologenesis in the nitrofen CDH model.
Title: Prenatal retinoic acid treatment upregulates late gestation lung protein 1 in the nitrofen-induced hypoplastic lung in late gestation.
Data show that in rat lung, glucocorticoid stimulates (7- to 115-fold) and Vitamin D suppresses (twofold) Lgl1 expression.
Title: Modulation of Lgl1 by steroid, retinoic acid, and vitamin D models complex transcriptional regulation during alveolarization.
lgl1 plays an important role in fetal airway branching morphogenesis.
Title: Antisense oligodeoxynucleotides decrease LGL1 mRNA and protein levels and inhibit branching morphogenesis in fetal rat lung.
Data suggest that deficiency of lgl1 contributes to the arrested alveolar partitioning observed in bronchopulmonary dysplasia and that recovery is associated with normalization of lgl1 levels.
Title: Lgl1 is suppressed in oxygen toxicity animal models of bronchopulmonary dysplasia and normalizes during recovery in air.
Lgl1 is imported by late gestation lung epithelial cells.
Title: Lgl1, a mesenchymal modulator of early lung branching morphogenesis, is a secreted glycoprotein imported by late gestation lung epithelial cells.

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General gene information

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Markers

Crispld2 (e-PCR), detects polymorphism
- UniSTS:525891

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables glycosaminoglycan binding	IBA Inferred from Biological aspect of Ancestor more info
enables glycosaminoglycan binding	ISO Inferred from Sequence Orthology more info
enables heparin binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within extracellular matrix organization	ISO Inferred from Sequence Orthology more info
involved_in face morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in lung development	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular matrix	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in transport vesicle	IEA Inferred from Electronic Annotation more info
located_in transport vesicle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cysteine-rich secretory protein LCCL domain-containing 2

Names: late gestation lung protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_138518.2 → NP_612527.2 cysteine-rich secretory protein LCCL domain-containing 2 precursor

See identical proteins and their annotated locations for NP_612527.2

Status: VALIDATED

Source sequence(s)

CA509993, CB732240, CK367026, CK600175, JAXUCZ010000019

UniProtKB/TrEMBL

A0A0G2JUW3, A6IZL4

Conserved Domains (3) summary

smart00603
Location:286 → 370

LCCL; LCCL domain

cd05380
Location:56 → 201

SCP_euk; SCP_euk: SCP-like extracellular protein domain, as found mainly in eukaryotes. This family includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5 from vespid venom. It has been proposed ...

pfam03815
Location:389 → 487

LCCL; LCCL domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086037.1 Reference GRCr8

Range

64961764..65020099

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006255708.5 → XP_006255770.1 cysteine-rich secretory protein LCCL domain-containing 2 isoform X1

See identical proteins and their annotated locations for XP_006255770.1

UniProtKB/TrEMBL

A0A0G2JUW3, A6IZL4

Related

ENSRNOP00000069254.3, ENSRNOT00000087857.3

Conserved Domains (3) summary

smart00603
Location:286 → 370

LCCL; LCCL domain

cd05380
Location:56 → 201

SCP_euk; SCP_euk: SCP-like extracellular protein domain, as found mainly in eukaryotes. This family includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5 from vespid venom. It has been proposed ...

pfam03815
Location:389 → 487

LCCL; LCCL domain