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Cyp2c22 cytochrome P450, family 2, subfamily c, polypeptide 22 [ Rattus norvegicus (Norway rat) ]

Gene ID: 171518, updated on 27-Nov-2024

Summary

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Official Symbol
Cyp2c22provided by RGD
Official Full Name
cytochrome P450, family 2, subfamily c, polypeptide 22provided by RGD
Primary source
RGD:620368
See related
EnsemblRapid:ENSRNOG00000021924 AllianceGenome:RGD:620368
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Cyp2c70; P-450Md; CYPIIC70
Summary
Predicted to enable arachidonate epoxygenase activity; heme binding activity; and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen. Predicted to be involved in epoxygenase P450 pathway and xenobiotic metabolic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Restricted expression toward (RPKM 4672.9) See more
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Genomic context

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See Cyp2c22 in Genome Data Viewer
Location:
1q54
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (248941143..248980767, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (238991698..239031323, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (259257658..259297270, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134485236 Neighboring gene U6 spliceosomal RNA Neighboring gene PDZ and LIM domain 1 Neighboring gene sorbin and SH3 domain containing 1 Neighboring gene uncharacterized LOC120097534

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Liver-specific cytochrome P450 CYP2C22 is a direct target of retinoic acid and a retinoic acid-metabolizing enzyme in rat liver. Qian L, et al. J Lipid Res, 2010 Jul. PMID 20147703, Free PMC Article
  2. cDNA and deduced amino acid sequences of a male dominant P-450Md mRNA in rats. Nagata K, et al. Nucleic Acids Res, 1990 Aug 25. PMID 2395662, Free PMC Article
  3. A different cytochrome P450 form is induced in primary cultures of rat hepatocytes. Emi Y, et al. Proc Natl Acad Sci U S A, 1990 Dec. PMID 2263625, Free PMC Article
  4. Nitric oxide and interleukin-1β stimulate the proteasome-independent degradation of the retinoic acid hydroxylase CYP2C22 in primary rat hepatocytes. Lee CM, et al. J Pharmacol Exp Ther, 2014 Jan. PMID 24144795, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CYP2C22 protein is rapidly downregulated in primary rat hepatocytes by interleukin(IL)-1beta or nitric oxide-donating compounds.
    Title: Nitric oxide and interleukin-1β stimulate the proteasome-independent degradation of the retinoic acid hydroxylase CYP2C22 in primary rat hepatocytes.
  2. Data demonstrate that CYP2C22 is a high-abundance, retinoid-inducible, hepatic P450 with the potential to metabolize at-RA, providing additional insight into the role of the CYP2C gene family in retinoid homeostasis.
    Title: Liver-specific cytochrome P450 CYP2C22 is a direct target of retinoic acid and a retinoic acid-metabolizing enzyme in rat liver.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables heme binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
  
enables monooxygenase activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables monooxygenase activity TAS
Traceable Author Statement
more info
 PubMed 
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in organic acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in xenobiotic metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in intracellular membrane-bounded organelle NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
cytochrome P450 2C70
Names
cytochrome P-450Md
cytochrome P450 2c22
cytochrome P450 P49
cytochrome P450, family 2, subfamily c, polypeptide 70
NP_612521.2
XP_038946459.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_138512.2 → NP_612521.2  cytochrome P450 2C70 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/Swiss-Prot
    P19225
    UniProtKB/TrEMBL
    A6JH55, B5AMZ7
    Conserved Domains (1) summary
    cd20665
    Location:61 → 484
    CYP2C-like; cytochrome P450 family 2, subfamily C, and similar cytochrome P450s

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    248941143..248980767 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039090531.1 → XP_038946459.1  cytochrome P450 2C70 isoform X1

    UniProtKB/Swiss-Prot
    P19225
    UniProtKB/TrEMBL
    A6JH55, B5AMZ7
    Related
    ENSRNOP00000051607.2, ENSRNOT00000054724.4
    Conserved Domains (1) summary
    cd20665
    Location:61 → 484
    CYP2C-like; cytochrome P450 family 2, subfamily C, and similar cytochrome P450s
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P19225.1 GenPept UniProtKB/Swiss-Prot:P19225

Gene LinkOut

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