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Dcxr dicarbonyl and L-xylulose reductase [ Rattus norvegicus (Norway rat) ]

Gene ID: 171408, updated on 27-Nov-2024

Summary

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Official Symbol
Dcxrprovided by RGD
Official Full Name
dicarbonyl and L-xylulose reductaseprovided by RGD
Primary source
RGD:620031
See related
EnsemblRapid:ENSRNOG00000081885 AllianceGenome:RGD:620031
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
glb
Summary
Enables L-xylulose reductase (NADPH) activity. Involved in glucose metabolic process and xylulose metabolic process. Predicted to be located in several cellular components, including brush border; cytoplasmic microtubule; and microvillus. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in pentosuria. Orthologous to human DCXR (dicarbonyl and L-xylulose reductase). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 680.0), Liver (RPKM 409.2) and 2 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Dcxr in Genome Data Viewer
Location:
10q32.3
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (106504730..106506619, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (106006404..106008293, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (109906119..109909696, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene 60S ribosomal protein L36a-like Neighboring gene leucine rich repeat containing 45 Neighboring gene Rac family small GTPase 3 Neighboring gene carbonyl reductase 2 Neighboring gene transfer RNA glycine (anticodon ACC) 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Identification of amino acid residues involved in substrate recognition of L-xylulose reductase by site-directed mutagenesis. Ishikura S, et al. Chem Biol Interact, 2003 Feb 1. PMID 12604240
  2. Molecular characterization of mammalian dicarbonyl/L-xylulose reductase and its localization in kidney. Nakagawa J, et al. J Biol Chem, 2002 May 17. PMID 11882650
  3. Involvement of an aldo-keto reductase (AKR1C3) in redox cycling of 9,10-phenanthrenequinone leading to apoptosis in human endothelial cells. Matsunaga T, et al. Chem Biol Interact, 2009 Sep 14. PMID 19442656
  4. MTR120/KIAA1383, a novel microtubule-associated protein, promotes microtubule stability and ensures cytokinesis. Fong KW, et al. J Cell Sci, 2013 Feb 1. PMID 23264731, Free PMC Article
  5. Proteomic characterization of the human sperm nucleus. de Mateo S, et al. Proteomics, 2011 Jul. PMID 21630459

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Dcxr is highly expressed in kidney and liver (dicarbonyl/L-xylulose reductase)
    Title: Molecular characterization of mammalian dicarbonyl/L-xylulose reductase and its localization in kidney.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables L-xylulose reductase (NADPH) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables L-xylulose reductase (NADPH) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables L-xylulose reductase (NADPH) activity ISO
Inferred from Sequence Orthology
more info
  
enables carbonyl reductase (NADPH) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables oxidoreductase activity, acting on CH-OH group of donors ISO
Inferred from Sequence Orthology
more info
  
enables oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in D-glucuronate catabolic process to D-xylulose 5-phosphate ISO
Inferred from Sequence Orthology
more info
  
involved_in D-xylose metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within NADP metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in glucose metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glucose metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in glucose metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of reactive oxygen species metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in xylulose metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in xylulose metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within xylulose metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in xylulose metabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in brush border ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic microtubule ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic microtubule ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in microvillus ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

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Preferred Names
L-xylulose reductase
Names
XR
diacetyl/L-xylulose reductase
dicarbonyl L-xylulose reductase
NP_599214.1
XP_038941084.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_134387.2 → NP_599214.1  L-xylulose reductase

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/Swiss-Prot
    Q920P0
    UniProtKB/TrEMBL
    A6HLI7, A6HLI8
    Related
    ENSRNOP00000108490.1, ENSRNOT00000168618.1
    Conserved Domains (1) summary
    cd05351
    Location:1 → 243
    XR_like_SDR_c; xylulose reductase-like, classical (c) SDRs

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    106504730..106506619 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039085156.2 → XP_038941084.1  L-xylulose reductase isoform X1

    Conserved Domains (1) summary
    cl21454
    Location:1 → 122
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q920P0.1 GenPept UniProtKB/Swiss-Prot:Q920P0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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