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Magea4 MAGE family member A4 [ Mus musculus (house mouse) ]

Gene ID: 17140, updated on 13-Jan-2025

Summary

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Official Symbol
Magea4provided by MGI
Official Full Name
MAGE family member A4provided by MGI
Primary source
MGI:MGI:1333839
See related
Ensembl:ENSMUSG00000033343 AllianceGenome:MGI:1333839
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mage-a4
Summary
Predicted to enable DNA-binding transcription factor binding activity; histone deacetylase binding activity; and ubiquitin protein ligase binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in PML body and cytosol. Predicted to be active in nucleus. Is expressed in several structures, including brain; egg cylinder; gonad; heart; and liver. Orthologous to several human genes including MAGEA10 (MAGE family member A10). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Low expression observed in reference dataset See more
Orthologs
human all
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Genomic context

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See Magea4 in Genome Data Viewer
Location:
X A7.3; X 37.2 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (71264599..71266611)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (72221015..72222964)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene cyclic nucleotide gated channel alpha 2 Neighboring gene STARR-seq mESC enhancer starr_47328 Neighboring gene STARR-seq mESC enhancer starr_47329 Neighboring gene STARR-seq mESC enhancer starr_47330 Neighboring gene STARR-seq mESC enhancer starr_47331 Neighboring gene STARR-seq mESC enhancer starr_47332 Neighboring gene predicted gene, 39519 Neighboring gene STARR-seq mESC enhancer starr_47333 Neighboring gene gamma-aminobutyric acid (GABA) A receptor, subunit epsilon Neighboring gene microRNA 224 Neighboring gene microRNA 452

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A cleaved form of MAGE-A4 binds to Miz-1 and induces apoptosis in human cells. Sakurai T, et al. J Biol Chem, 2004 Apr 9. PMID 14739298
  2. MAGE cancer-testis antigens protect the mammalian germline under environmental stress. Fon Tacer K, et al. Sci Adv, 2019 May. PMID 31149633, Free PMC Article
  3. A new family of mouse genes homologous to the human MAGE genes. De Plaen E, et al. Genomics, 1999 Jan 15. PMID 9933564
  4. Expression dynamics of Mage family genes during self-renewal and differentiation of mouse pluripotent stem and teratocarcinoma cells. Gordeeva O, et al. Oncotarget, 2019 May 14. PMID 31143371, Free PMC Article
  5. An overview of the MAGE gene family with the identification of all human members of the family. Chomez P, et al. Cancer Res, 2001 Jul 15. PMID 11454705

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. a cleaved form of MAGE-A4 binds to Miz-1 and induces apoptosis
    Title: A cleaved form of MAGE-A4 binds to Miz-1 and induces apoptosis in human cells.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Clone Names

  • MGC123681, MGC123682

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
  
enables histone deacetylase binding ISO
Inferred from Sequence Orthology
more info
  
enables molecular_function ND
No biological Data available
more info
  
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in PML body ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
melanoma-associated antigen 4
Names
melanoma antigen, family A, 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020280.3 → NP_064676.2  melanoma-associated antigen 4

    See identical proteins and their annotated locations for NP_064676.2

    Status: VALIDATED

    Source sequence(s)
    AL671874
    Consensus CDS
    CCDS30185.1
    UniProtKB/TrEMBL
    F2Z493, Q3SXV1
    Related
    ENSMUSP00000046715.2, ENSMUST00000048675.2
    Conserved Domains (2) summary
    pfam01454
    Location:161 → 271
    MAGE; MAGE family
    pfam12440
    Location:16 → 84
    MAGE_N; Melanoma associated antigen family N terminal

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    71264599..71266611
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011247539.2 → XP_011245841.1  melanoma-associated antigen 4 isoform X1

    Conserved Domains (2) summary
    pfam01454
    Location:161 → 271
    MAGE; MAGE family
    pfam12440
    Location:16 → 84
    MAGE_N; Melanoma associated antigen family N terminal
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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