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Bnipl BCL2/adenovirus E1B 19kD interacting protein like [ Mus musculus (house mouse) ]

Gene ID: 171388, updated on 27-Nov-2024

Summary

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Official Symbol
Bniplprovided by MGI
Official Full Name
BCL2/adenovirus E1B 19kD interacting protein likeprovided by MGI
Primary source
MGI:MGI:2384749
See related
Ensembl:ENSMUSG00000028115 AllianceGenome:MGI:2384749
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PP73; PP753; BNIP-S; BNIPL1; BNIPL2; 1700128A13Rik
Summary
Predicted to enable identical protein binding activity. Predicted to be involved in apoptotic process; negative regulation of cell population proliferation; and regulation of growth rate. Predicted to be located in cytosol and nucleus. Predicted to be active in cytoplasm. Is expressed in several structures, including embryo endoderm; genital tubercle; and urinary system. Orthologous to human BNIPL (BCL2 interacting protein like). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in stomach adult (RPKM 4.7), bladder adult (RPKM 4.5) and 11 other tissues See more
Orthologs
human all
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Genomic context

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See Bnipl in Genome Data Viewer
Location:
3 F2.1; 3 40.74 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (95148587..95158504, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (95241276..95252144, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene GA repeat binding protein, beta 2 Neighboring gene STARR-seq mESC enhancer starr_08372 Neighboring gene predicted gene, 16740 Neighboring gene myeloid/lymphoid or mixed-lineage leukemia; translocated to, 11 Neighboring gene CDC42 small effector 1 Neighboring gene predicted gene 128 Neighboring gene prune exopolyphosphatase Neighboring gene STARR-positive B cell enhancer ABC_E2672 Neighboring gene MINDY lysine 48 deubiquitinase 1 Neighboring gene annexin A9 Neighboring gene STARR-positive B cell enhancer ABC_E9560 Neighboring gene predicted gene, 53243 Neighboring gene ceramide synthase 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Molecular Characterization of the Genital Organizer: Gene Expression Profile of the Mouse Urethral Plate Epithelium. Armfield BA, et al. J Urol, 2016 Oct. PMID 27173853, Free PMC Article
  2. Prospective isolation and global gene expression analysis of definitive and visceral endoderm. Sherwood RI, et al. Dev Biol, 2007 Apr 15. PMID 17328885
  3. The in vivo brain interactome of the amyloid precursor protein. Bai Y, et al. Mol Cell Proteomics, 2008 Jan. PMID 17934213
  4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • MGC8103

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of growth rate ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
bcl-2/adenovirus E1B 19 kDa-interacting protein 2-like protein
Names
BNIP-2 similar

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001168356.1 → NP_001161828.1  bcl-2/adenovirus E1B 19 kDa-interacting protein 2-like protein isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks two in-frame exons in the coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC140190, AK142472
    Consensus CDS
    CCDS50988.1
    UniProtKB/TrEMBL
    E9Q8I3, Q3UQG4
    Related
    ENSMUSP00000096468.5, ENSMUST00000098871.11
    Conserved Domains (2) summary
    cd00170
    Location:209 → 264
    SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...
    pfam12496
    Location:50 → 178
    BNIP2; Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2

  2. NM_134253.2 → NP_599014.2  bcl-2/adenovirus E1B 19 kDa-interacting protein 2-like protein isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC140190
    Consensus CDS
    CCDS17609.2
    UniProtKB/Swiss-Prot
    Q923E3, Q99JU7
    UniProtKB/TrEMBL
    E9QME1
    Related
    ENSMUSP00000102813.3, ENSMUST00000107195.9
    Conserved Domains (1) summary
    cd00170
    Location:194 → 340
    SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    95148587..95158504 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030252448.2 → XP_030108308.1  bcl-2/adenovirus E1B 19 kDa-interacting protein 2-like protein isoform X1

    UniProtKB/Swiss-Prot
    Q923E3, Q99JU7
    Conserved Domains (2) summary
    pfam12496
    Location:50 → 178
    BNIP2; Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2
    pfam13716
    Location:180 → 317
    CRAL_TRIO_2; Divergent CRAL/TRIO domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99JU7.1 GenPept UniProtKB/Swiss-Prot:Q99JU7

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